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  • Quinoline-based tetrazolium prochelators: formazan release, iron sequestration, and antiproliferative efficacy in cancer cells

    Sung, Yu-Shien; Tomat, Elisa; Department of Chemistry and Biochemistry, The University of Arizona (Royal Society of Chemistry (RSC), 2024-05-28)
    Iron-binding strategies in anticancer drug design target the key role of iron in cancer growth. The incorporation of a quinoline moiety in the design of tetrazolium-based prochelators facilitates their intracellular reduction/activation to iron-binding formazans. The new prochelators are antiproliferative at submicromolar levels, induce apoptosis and cell cycle arrest, and impact iron signaling in cancer cells.
  • Emergency Physicians’ Ethical Issues with Hospital Business Models

    Iserson, Kenneth V.; Paxton, James H.; Martin, Daniel R.; Marcolini, Evie; Department of Emergency Medicine, The University of Arizona (Elsevier BV, 2024-03-12)
    Background: The changing hospital business model has raised ethical issues for emergency physicians (EPs) in a healthcare system that often prioritizes profits over patient welfare. For-profit hospitals, driven by profit motives, may prioritize treating patients with lucrative insurance plans and those who can afford expensive treatments. Private equity investors, who now own many for-profit hospitals, focus on short-term financial gains, leading to cost-cutting measures and pressure on EPs to prioritize financial goals over patient welfare. Nonprofit hospitals, mandated to provide charity care to the underserved, may fail to meet their community service obligations, resulting in disparities in healthcare access. Objective: This review examines the ethical challenges faced by emergency physicians (EPs) in response to the evolving hospital business model, which increasingly prioritizes profits over patient welfare. Discussion: Emergency physicians face ethical dilemmas in this changing environment, including conflicts between patient care and financial interests. Upholding professional ethics and the principle of beneficence is essential. Another challenge is equitable access to healthcare, with some nonprofit hospitals reducing charity care, thus exacerbating disparities. EPs must uphold the ethical principle of justice, ensuring quality care for all patients, regardless of financial means. Conflicts of interest may arise when EPs work in hospitals owned by private equity firms or with affiliations with pharmaceutical companies or medical device manufacturers, potentially compromising patient care. Conclusion: Emergency physicians must navigate these ethical issues while upholding professional ethics and advocating for patients' best interests. Collaboration with hospital administrators, policymakers, and stakeholders is vital to address these concerns and prioritize patient welfare in healthcare delivery.
  • An ontology‐based digital test and evaluation master plan (dTEMP) compliant with DoD policy

    Gregory, Joe; Salado, Alejandro; Department of Systems and Industrial Engineering, The University of Arizona (Wiley, 2024-05-28)
    Test and evaluation (TE) planning is a critical part of systems engineering. However, it has not received as much attention from digital engineering efforts as early-stage design and analysis. Digital engineering has the potential to reduce the risk and effort associated with TE, while leveraging existing digital capabilities to add value. One aspect in particular that may benefit from such attention is the Department of Defense's Test and Evaluation Master Plan (TEMP). The purpose of the TEMP is to identify the key processes with respect to the TE of a product, and to specify the roles and responsibilities of key personnel and organizations. Concerns have been raised regarding the document-based nature of the TEMP and the increased risk and reduced reward that this entails. In this paper, we investigate the potential benefits of digitalizing the TEMP and outline an incremental approach for achieving this. We also present a set of ontologies, collectively known as the Digital TEMP (dTEMP), and investigate potential benefits and limitations by applying the dTEMP to an example test program.
  • Race, Data, and Classics

    Park, Arum; University of Arizona (Project MUSE, 2024-04-26)
    The focus of this article is a 2019–2020 demographic data collection, visualization, and analysis project on race and Classics. Based on the findings of the project, this article advances arguments in favor of regular, frequent, and well-publicized demographic data gathering and visualization as practices crucial for effective, research-driven diversity and inclusion efforts in Classics. By fueling and bolstering these efforts, such practices have the potential to expand and reshape the boundaries of Classics as a discipline.
  • A qualitative analysis of student pharmacists' perceptions working in community settings during the COVID-19 pandemic

    Bingham, Jennifer M; Maldonado, Taylor; Axon, David R; Department of Pharmacy Practice & Science, R. Ken Coit College of Pharmacy, University of Arizona (Elsevier Inc., 2024-05-24)
    Introduction: Student pharmacists made a considerable contribution to healthcare provision and public health efforts during the COVID-19 pandemic. However, little is known about student pharmacists' experiences working in community pharmacy during the COVID-19 pandemic. This study aimed to describe the perceived impact of the COVID-19 pandemic on student pharmacists working in community-based pharmacy settings. Methods: Semi-structured interviews were conducted in Spring 2023 with student pharmacists enrolled in the Doctor of Pharmacy program at the University of Arizona R. Ken Coit College of Pharmacy who also worked at a community pharmacy during the COVID-19 pandemic. Students were asked five core questions with additional probing questions as necessary. Students were also asked to provide three words that described their experience working in community pharmacy through the COVID-19 pandemic. Interviews were audio-recorded and transcribed, then coded by two independent reviewers with differences resolved through consensus. Results: Eighteen students participated in a semi-structured interview. Four key themes were identified: (1) health and wellness of self and others; (2) education (online didactic and experiential) and work experience; (3) pharmacy workforce; and (4) appreciation and value of the pharmacy profession. The most common words to describe working in community pharmacy through the COVID-19 pandemic were stressful (n = 7) and rewarding (n = 5). Conclusions: This study offers some insight into the experiences of student pharmacists from one United States school of pharmacy working in community pharmacy during the COVID-19 pandemic. Future work is warranted to assess the long-term impact on student pharmacist wellbeing, education, work experience, and appreciation of the profession.

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