Not primarily in methods or content
But in the breakdown in connections between:
"Although the specific topics will evolve on the basis of the interests of the participants, we expect that there will be a focus on promoting inquiry-centered learning...we're trying to provide a space for dialogue about more divergent and student-centered kinds of teaching and learning."
Mary: All we do is pour a little bit more strawberry in it [Sue gets a small plastic cup from the back table and asks Mary to "put it in here"], and a little bit of ice cream, and then [Sue puts the cup she had gotten down right next to the large plastic cup, apparently to give Mary another chance to put the shake in there], done. Shake it up [tries covering the large plastic cup with the small plastic cup Sue had gotten and seems to think it's too small, so she empties out another large plastic cup holding pencils and rulers and uses it inverted as a top for shaking], and give it to the window [hands the shake toward the imaginary window to the left of the screen].
Brown, Beck, Frazier, & Rath, 1996
Is it science?
"Genuine intellectual integrity is found in experimental knowing." John Dewey

Inquiry is the controlled or directed transformation of an indeterminate situation into one that is so determinate in its constituents distinctions and relations as to convert the elements of the original situation into a unified whole" (Logic: The Theory of Inquiry, p. 108).
The moment when understanding and action come into dynamic and reciprocal relationship with one another is the moment when inquiry for both students and teachers truly comes alive.