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Regional Development in the Knowledge-Based Economy: The Construction of Advantage. Introduction to the Special Issue. Journal of Technology Transfer, 31 (1), 2006, 5-15.Cooke, Phil; Leydesdorff, Loet (2006)In this introduction the editors showcase the papers by way of a structured project and seek to clarify the two key concepts cited in the title. We consider the history of the idea that knowledge is an economic factor, and discuss the question of whether regions provide the relevant system of reference for knowledge-based economic development. Current transformations in university-industry-government relations at various levels can be considered as a metamorphosis in industry organization. The concept of constructed advantage will be elaborated. The various papers arising from a conference on this subject hosted by Memorial University, Newfoundland, Canada are approached from this perspective.