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The attachment of quinolone based antibiotics to metallic biomaterials
A simple and effective technique for the deposition of ciprofloxacin HCl salt onto pore coated Ti-6Al-4V alloy rods has been investigated for the prevention of infection in orthopedic applications. This technique involves the electrophoretic deposition of negatively charged ciprofloxacin particles as well as the precipitation of ciprofloxacin anions on positively biased rods. Experimental variables such as applied voltage, coating time, and pH of the antibiotic solution have been investigated in terms of the amount of deposited antibiotic, the morphology of antibiotic coating, the rate of release of deposited ciprofloxacin and the antibacterial activity of the coated samples against Staph aureus and Staph epidermidis.