• Disposition kinetics of Amphotericin-B in rats

      Mayersohn, Michael; Cai, Yuli, 1961- (The University of Arizona., 1991)
      The disposition kinetics of Amphotericin-B (Am-B) were investigated in rats in three different dose groups. Each group contained four rats. The serum and urine Am-B concentrations were analyzed by reversed-phase HPLC. There were no significant differences for total body clearance and half-lives as a function of dose. Those observations suggested systemic dose-independent behavior of Am-B. However, renal clearance of Am-B decreased significantly as Am-B dose increased; whereas, no renal damage was observed during the experiment. The present studies suggested that renal clearance was dose-dependent and that there may be a saturable tubular secretion process for Am-B renal excretion.