• Upstream Regulators of TORC1 Signaling Pathway in Saccharomyces cerevisiae

      Capaldi, Andrew; Vaishampayan, Prajakta; Capaldi, Andrew; Gutenkunst, Ryan; Paek, Andrew (The University of Arizona., 2019)
      Many nutrients including glucose, phosphate and amino acids regulate TORC1 activity and when the cells are in stress or starvation conditions, TORC1 activity is inhibited. It remains unclear how this happens. So, we are interested in mapping the signaling system that talks to TORC1 to ultimately understand how the complex integrates signals to control growth in stress conditions. In this project, the response of TORC1 under nitrogen, glucose and phosphate starvation conditions was checked in strains lacking one or more stress signaling pathway proteins to identify the mechanism which leads to inhibition of TORC1 in stress conditions.