Now showing items 13357-13376 of 14576

    • T. E. Brown as revealed in his letters and poems

      Felmley, Mildred H. (The University of Arizona., 1931)
    • T. H. Huxley's defense of Charles Darwin's Origin of species

      Harvey, Mary Jolyne, 1934- (The University of Arizona., 1960)
    • Tabasco wilt: nature of host-virus interaction

      Zouba, Ali, 1949- (The University of Arizona., 1977)
    • The Tachinid flies of Arizona

      Simpson, Roy William, 1931- (The University of Arizona., 1957)
    • A tactical analysis of the Sino-Soviet dispute

      Hayes, Louis D. (The University of Arizona., 1964)

      Thornton, Susan Ruth. (The University of Arizona., 1984)
    • Taft and Mexico: neutrality, intervention and recognition, 1910-1913

      Farrier, Paul Everest, 1934- (The University of Arizona., 1966)
    • Tailings pond seepage and sulfate equilibrium in the Pima mining district, Pima County, Arizona

      Scovill, Georgia Lynn, 1962- (The University of Arizona., 1988)
      Mining activity is suspected of contributing sulfate and total dissolved solids (TDS) to ground water downgradient of the Pima mining district. High ionic concentrations in tailing impoundments suggest that tailings-pond recharge may be a source of the contamination. Experiments indicated that sulfate is not significantly produced by inorganic sulfide oxidation in the tailings ponds. Tailings pond water chemistries were compared with historical water quality analyses in the Pima district. The U.S.G.S. computer program PHREEQE modeled saturation indices for anhydrite, calcite, fluorite, and gypsum in water chemistries throughout the study area. Well water downgradient of the mines had lower saturation indices than tailings pond water which discredits the claim that tailings-pond recharge is acquiring salts as it percolates to the aquifer. Evidence supports the opinion that tailings pond seepage is contributing to the sulfate and TDS content in ground water downgradient of the ponds.
    • Taisho Modan and the Cultural Space of the Taisho Period

      Inoue, Kota (The University of Arizona., 1995)
    • Taiwan and the Bush administration's Mainland China policy, January 1989-December 1992

      Wang, Xueliang, 1956- (The University of Arizona., 1993)
      This thesis divides Taiwan's impact on the Bush administration's Mainland China policy into three stages. The first period was from January 1989, when George Bush entered the White House, to June 3, when the Tiananmen Massacre took place in Beijing. The second period was from June 1989 to July 1991. The third period was from July 1991 to the end of 1992. Through examining the Bush administration's Mainland China policy, this thesis argues that Taiwan's impact on the administration's China policy evolved a tract from unimportant to important in the years between 1989 and 1992. It further argues that Taiwan has become an independent factor, whose China policy was not under the control of the United States. Sometimes it undermined American Mainland China policy.
    • Taiwan's economic miracle: Presentations of culture and ideology

      Harris, Courtney Ann, 1965- (The University of Arizona., 1992)
      Native commentators on Taiwan's recent industrialization consider culture a key factor of the nation's modernization drive. Indigenous writers present Chinese culture as not only economically fit, but also morally superior. Such presentations, I argue, have unspoken ideological goals. Legitimation of the government, paternalistic claims on citizens and workers by the state and employers, and the rhetorical war against communism are some of the tacit agendas I discuss.
    • Taiwanese nurses' knowledge and attitudes toward persons with AIDS

      Chen, Mei-Yuh, 1963- (The University of Arizona., 1993)
      The purpose of this descriptive study was to describe Taiwanese nurses' knowledge about and attitudes toward persons with AIDS (PWAs). One hundred and two subjects were recruited from three large medical centers in Taiwan during December, 1992 and January, 1993. A backtranslated Chinese version AIDS Vulnerability Survey (AVS) was used to measure Taiwanese nurses' knowledge of AIDS and attitudes toward persons with AIDS. Findings of this study indicated that Taiwanese nurses lack knowledge of AIDS, have negative attitudes toward PWAs, and perceived themselves highly vulnerable to AIDS. A positive relationship was found between attitudes toward PWAs and length of work experience (r = -.28, p ≤ .05). Significant differences were found between marital status and attitudes toward PWAs (t = -2.58, p ≤ .05), indicating that married nurses had more positive attitudes toward PWAs than single nurses.
    • Talker Discrimination in Preschool Children with and without Specific Language Impairment

      Dailey, Natalie S. (The University of Arizona., 2013)
      Variability inherently present between multiple talkers can prove beneficial in the context of learning. However, the performance during learning paradigms by children with specific language impairment (SLI) remains below typically developing peers, even when multiple talkers are used. Preschool children with typically developing language (n = 17) and SLI (n = 17) participated in a talker discrimination task. Five different pairings of talkers (same male, different males, same female, different females, male + female) were used to present 50 spoken words. Children with SLI were significantly poorer in discriminating same and different male speakers compared to their typical peers. The present findings demonstrate that preschool children with SLI can experience difficulty distinguishing between talkers. Poor sensitivity to variation in talkers may contribute to poor learning in SLI for contexts where multiple talker input should benefit the learner.
    • Talking about women and AIDS: Normative discourses on sexuality

      Sacks, Valarie Lynne, 1966- (The University of Arizona., 1994)
      A close reading of popular discourses on women and the AIDS epidemic reveals patterns that could be described as attempts to produce and reiterate notions of normative and deviant sexuality. Prostitutes, one frequently depicted "kind" of woman, are presented as indiscriminate, polluting to men, and categorically different from "normal" women. Other women depicted in AIDS discourses are almost always HIV-positive mothers or pregnant women; these women are usually only of concern insofar as they may infect their babies. The themes of self-control, self-discipline, and personal responsibility may also be used to stigmatize women. Such discourses suggest that those who have AIDS are responsible for their own illness. They also deflect attention away from the socioeconomic contexts which may make it more difficult for some to avoid infection, away from the connections between poverty, illness, and disempowerment, and away from the systematic inequalities that characterize U.S. society.
    • The talking circle

      Duffié, Mary Katharine (The University of Arizona., 1989)
      The text and accompanying video tape describe the "talking circle" ritual as it is being used spiritually by a Native American group in Southern Arizona. The text analyzes the evolution of the ritual and applies widely accepted models of group therapy to its uses in the following capacities: Spiritually, (and in) Substance Abuse, Education and the Psychological Treatment of Troubled Teen-agers. The video tape features interviews with local practitioners and is narrated by a traditional Chippewa Indian.
    • Targeting Trafficking of Voltage Gated Calcium Channels: A Novel Approach in the Treatment of Pain

      Wang, Yue (The University of Arizona., 2015)
      Pain is the most common and debilitating medical problem for which patients seek medical care. Opioids remain the gold standard in the treatment of pain but are limited by poor side effect profiles such as emesis, constipation, dependence/addiction and respiratory depression. Despite a myriad of analgesic compounds on the market, tri-cyclic antidepressants, opioids, anticonvulsants, non-steroidal anti-inflammatory agents and combinations thereof, nearly two thirds of the chronic pain patients report inadequate pain relief; therefore, a new approach in the development of pain management is necessary. In recent years, the N-Type voltage gated calcium channel (CaV2.2) has become an attractive target in the treatment of chronic pain. Ziconotide, a selective CaV2.2 blocker, has been FDA approved in the United States for the treatment of severe chronic pain that is refractory to other treatments, but due to its profound side effect profile (nausea/vomiting, somnolence, vertigo, muscle spasms, myalgia, insomnia, anxiety, tremor, memory impairment and induced psychiatric disorders), the use of Ziconotide is severely limited. Mapping of the CaV2.2 interactome led to the identification of novel regulatory proteins, including collapsin response mediator protein 2 (CRMP2). Initially identified as an intracellular protein in the specification of axon/dendrite fate and axonal outgrowth, it is now known that this protein can regulate the activity of CaV2.2 and hence may be a critical regulatory node in pain modulation. Here, I describe a novel peptide aptamer derived from CRMP2, designated CaV2.2 binding domain 3 (CBD3), which when fused with the HIV transactivator of transcription protein (TAT), created tat-CBD3, which was able to significantly reverse thermal and mechanical hypersensitivity induced by the surgical incision on the plantar surface of the left hind paw in rats, a pre-clinical model of post-operative pain. Additionally, tat-CBD3 significantly attenuated thermal hypersensitivity induced via intraplantar injection of carrageenan, a model of acute inflammatory pain. Furthermore, the administration of tat-CBD3 did not produce any rewarding behaviors as measured by the conditioned placed preference (CPP) paradigm, nor did the administration of tat-CBD3 produced any motor coordination deficits measured using the rotarod performance test. Moreover, the addition of a 14-carbon myristate (myr) group to the parent peptide, myr-tat-CBD3, had increased efficacy in the attenuation of paw incision and carrageenan induced thermal/mechanical hypersensitivities when compared to the parent peptide (tat-CBD3). These types of novel compounds that lack unwanted side effects and addiction propensities are urgently needed to relieve individuals suffering from chronic pain.