Dissertations: Recent submissions
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Essays in Philosophy, Economics, and LawThis Ph.D. dissertation comprises three chapters that are designed to stand independently but collectively explore the relationship between markets, individual agency, and normative systems.CHAPTER I, The Morality of Market Defense, examines the permissibility of market activism—specifically market vigilantism—as a means of effecting social change outside democratic procedures. CHAPTER II, Agency and Markets, challenges the strong libertarian claim that markets inherently achieve efficient allocations while simultaneously maximizing individual agency. CHAPTER III, Deregulating Contracts, advocates for the liberalization of procedural rules in commercial contract law for sophisticated parties, grounded in both consequentialist and deontological reasoning. Despite their varied topics, these chapters are unified by methodological, thematic, and normative dimensions. Methodologically, they adopt an interdisciplinary approach that combines economic theory with the normative and conceptual analysis of political philosophy. Thematically, they argue that under the ideal conditions of complete markets, as described by Arrow-Debreu general equilibrium theory, individual agency and normative systems become instrumentally irrelevant. In such markets, agency is minimized, and moral and legal rights largely lose their significance. Conversely, the opposite holds in incomplete markets. Normatively, the dissertation collectively rejects strong libertarianism. This rejection is explicit in CHAPTER II and implicit in CHAPTER I, where the critique of common good anarchism reveals inconsistencies with democratic principles. In CHAPTER III, while advocating for procedural freedom for sophisticated parties, the dissertation acknowledges that substantive contractual freedom may justifiably be restricted for both consequentialist and deontological reasons.
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A Study on Korean Art Song Tradition with Emphasis on Vocal Works by Female Composers: Hanbyeol Kang, Wonju Lee, Soon-Ae Kim, and JaeEun ParkThe Korean art song, Gagok (가곡), a genre rooted in the traditional poetic form Sijo and influenced by Western hymnals, has evolved significantly throughout the 20th and 21st centuries. English hymnals were introduced to late nineteenth-century Korea by the missionaries Horace G. Underwood (1859–1916) from a Northern Presbyterian mission and Henry G. Appenzeller (1858–1902) from a Northern Methodist mission. Throughout the period of Japanese rule over Korea from 1910 to 1945, Changga (창가) emerged as a form of secular song that aimed to promote the ideology of civilization development and independence while fostering a sense of patriotism. Public interest in art songs increased through 1960 with larger concerts, private recitals, recordings, and broadcasts. With the establishment of the Korean Composer Association (대한 음악가 협회) in the early 1960s, art song composition became more prevalent. Composers in the 20th and early 21st centuries started composing songs in their unique style.This study examines the works of four female composers– Hanbyeol Kang (b.1993), Wonju Lee (b.1979), Soon-Ae Kim (1920–2007), and JaeEun Park (b.1956)– to explore how they have used art songs to reflect and challenge the historical and social contexts of Korea. New beliefs, internal strife, and social upheavals in Korean culture influenced their cultural and artistic innovation in music. Through a feminist lens, this study analyzes how these composers’ works have contributed to a broader understanding of Korean women’s experiences and struggles. Drawing inspiration from female poets of various eras, these composers offered a unique perspective on the complexities of gender roles and societal expectations. Female composers in the 20th and 21st centuries have been influenced by Korean female poets, creating music that reflects historical events. Those poetic works are of female poets from the Joseon Dynasty, such as Nanseolheon Huh (1563–1589) and Maechang Yi (1573–1610), as well as modern poets, such as Namjo Kim (1927–2003) and Jeonghee Go (1948–1991). The four composers incorporated Korean cultural elements into their vocal works, inspired by the works of Korean female poets and traditional musical elements. Their poetry frequently delved into the complex issues of female social status in the Joseon Dynasty, and the broader social and political upheavals of the Korean War and the Gwangju Democratization Movement. Furthermore, this study provides an in-depth exploration of selected art songs and overview of Korean Art songs. It explores distinctive textual elements, traditional instrumentation, and cultural influences that shaped Korean art song as a genre. The study delves into the use of unique Korean textual elements, traditional instruments, and cultural influences. It explores distinctive textual elements, traditional instrumentation, and cultural influences that shaped Korean art song as a genre. The study delves into the use of unique Korean textual elements, traditional instruments, and cultural influences.
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Improving Cultural Competency: Educating Healthcare Providers Serving an American Indian/Alaskan Native PopulationPurpose: To increase the knowledge, awareness, and ability to provide culturally competentcare, with a focus on culture and beliefs, resources in the community, and patient behaviors among healthcare providers serving an ethnically diverse population. Background: Majority of the healthcare providers serving American Indian/Alaskan Native (AIAN) communities are non-AIAN, do not inherently possess the knowledge and understanding of the community and cultures, and often do not receive culturally competent education or training on the community they serve. This is concerning and can have a negative impact on healthcare delivery and patient outcomes. Methods: An introductory Pascua Yaqui Tribe cultural competence educational session (PCCES) was created for current and new providers at an outpatient primary clinic located on the reservation. Voluntary pre- and post-survey questionnaires were used to assess participants' knowledge and likelihood of providing culturally competent care. Results: The educational training had a positive impact on providers caring for AIAN in an outpatient primary care setting. The survey results of the QI project support that the introductory PCCES increased participants' cultural competency knowledge, benefited their healthcare practices, and increased their confidence to provide culturally competent care.
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Technostress and Contributing Factors among Hospital NursesBackground: Technostress poses a significant challenge to the nursing profession, with far-reaching implications for nurses' health, well-being, and patient care. Despite this, little is known about technostress among hospital nurses working in the United States (US). Purpose/Aims: The purpose of this study was to examine technostress among hospital nurses and its relationships with hospital characteristics (magnet status, type of EHR used, and if the location is a teaching hospital), current work characteristics (hospital department, weekly hours worked, frequency of floating departments, and years of experience at current hospital), cumulative work experience (years of experience as a nurse and years of experience using EHRs), EHR usability, cognitive workload, and EHR unintended consequences (EHR-UC). Methods: This study used a cross-sectional descriptive design. Participants (n=153) were recruited online via social media and recruitment platforms over a period of 10 weeks. Data were collected using an online Qualtrics survey containing a demographic questionnaire and validated instruments to measure technostress, EHR usability, cognitive workload, and EHR-UC. Data analysis was conducted in Stata 16.1 using one-way analysis of variance, Spearman correlations, and multiple linear regression. Findings: The average level of overall technostress was moderate (M= 2.54; SD = 0.61), on a scale of 1 to 5. Only one technostress inhibitor (technical support provision) showed a significant, small negative correlation with technostress, r (153) = -.21, p = .01. The frequency of floating between departments was the only work characteristic significantly associated with technostress (F= 3.41, p= .04). No significant relationships were found between technostress and other hospital characteristics or cumulative work experience. Significant predictors of technostress included EHR usability, cognitive workload, and EHR-UC. The final regression model showed that EHR usability, cognitive workload, and EHR-UC collectively explained 41% of the variance in technostress, F (3,128) = 31.84, p <.001, Adjusted R²=0.41. Conclusions/Implications: These findings highlight the complex relationships between technostress and various organizational and technological factors in hospital environments. By understanding the factors contributing to technostress and implementing strategies to mitigate its effects, nursing organizations and individuals can create healthier and more supportive work environments for nurses. Future research is needed to explore this important issue.
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Investigating the Role of Nuclear EGFR in Regulating the Tumor Immune Microenvironment in Breast CancerEGFR functions as an oncogene via multiple pathways, including kinase-dependent signal transduction, calcium release, and through its function as a nuclear transcription co-factor. These pathways are involved in proliferation, survival, migration, and regulation of the tumor immune microenvironment (TIME). Although much is known about how EGFR signaling alters the TIME, little is known about the effect nuclear EGFR (nEGFR) has on regulating TIME in breast cancer. Considering that both EGFR signaling and nEGFR are oncogenic, it is possible that both function to create a tumor microenvironment that is conducive for tumor growth.Our findings demonstrate the effect EGFR signaling has on regulating TIME via the activation of the NF-κB pathway and thus, secretion of cytokines like IL-6, IL-8, and CXCL1, which are involved in the inflammatory response and the recruitment of monocytes/macrophages and neutrophils to the tumor microenvironment. This effect can be inhibited using EGFR tyrosine kinase inhibitors like erlotinib and sapitinib. In addition, we demonstrated the role of nEGFR in regulating TIME using novel peptide therapeutics, SAH5-EJ1 and cSNX1.3, cells modified to lack a nuclear localization sequence (EGFRΔNLS), and cells with MUC1 knockdown, showing that nEGFR suppresses the expression of cytokines and ligands involved in leukocyte-mediated immunity. Specifically, we demonstrated nEGFR suppresses the expression of IL-6, a cytokine known to have anti-tumor properties due to its effects on leukocyte survival, proliferation, differentiation, and recruitment. Via RNA-Seq and spatial transcriptomics, we showed that nEGFR suppresses the expression of natural killer (NK) cell activating receptor ligands and cytokines important for NK cell-mediated killing and recruitment. To test the impact this has on NK cell- mediated immunity, we inhibited nEGFR with cSNX1.3 and demonstrated enhanced NK cell- mediated killing. Targeting EGFR signaling did not result in the regulation of these ligands, cytokines, and NK cell-mediated killing, thereby highlighting a potentially key role of nEGFR- mediated oncogenesis. Together, these data reveal how EGFR signaling and nEGFR impact TIME in breast cancer. Although both function to create a pro-tumorigenic microenvironment, it is important to note the distinct ways in which they regulate TIME. This dissertation analyzes both the signal transduction impact of EGFR on TIME through activation of the NF-κB pathway and the role of nEGFR on TIME in regulating tumor growth.
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Educating Primary Care Providers on Plant-Based Nutrition to Decrease Cardiovascular DiseasePurpose: The purpose of this quality improvement (QI) project was to increase and improve PCPs’ education on the benefits of incorporating a plant-based diet to improve cardiovascular health. The primary care providers were then encouraged to educate their patients that suffer from cardiovascular disease or at risk of cardiovascular disease on the benefits of integrating a plant-based diet in their treatment plan in hopes they will adopt changes to their diet. Background: Cardiovascular disease continues to be the leading cause of mortality remaining a public health crisis. Cardiovascular disease progresses overtime, therefore slowing progression by having appropriate lipid levels is key. Healthy behaviors such as a healthy diet can help in treating and slowing down cardiovascular disease. Healthy plant-based diets have been shown to improve cardiovascular health. Health care professionals need to be prepared to address nutrition to patients as they have a vital role in providing nutritional care. Methods: Guided by the Model for Improvement, healthcare professional participants completed an online educational PowerPoint followed by a pre-post survey to measure a change in participant knowledge and intent to recommend a plant-based to patient with or at risk of cardiovascular disease. Results: All 3 healthcare participants were recruited and agreed to take part in the educational module followed by the pre-post survey. The results of the survey indicated that the educational PowerPoint increased their knowledge on the benefits of a plant-based diet on cardiovascular disease. All participants also agreed to recommend a plant-based diet to their patients. Conclusion: Study findings supported the aim of this quality improvement project. The results indicate that education to providers can help achieve improved knowledge of plant-based nutrition on cardiovascular disease. This encourages providers to recommend a plant-based diet to their patients. Future efforts should include a wider dissemination incorporating more providers and evaluating provider education in hopes they will communicate the benefits of plant-based nutrition to their patients.
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Utilization of a Palliative Care Team to Improve Rural Chronic Care: A Feasibility StudyPurpose: To determine if it is feasible for San Luis Valley Health to implement a new palliative care service line to improve rural chronic care. Background: Colorado hospitals are facing increasing financial and operational challenges. Rural populations are known to be older and sicker than their urban counterparts, and there are fewer options for safe discharge at the end of life. Not only is the San Luis Valley rural, but it is also large and geographically isolated from tertiary healthcare. Methods: Primary Care Providers were surveyed regarding their knowledge of palliative care and their patients' understanding and perception of it. They were also asked if they had an interest in palliative care. Hospital data were obtained and compared to known national data to ascertain the potential financial impact of a palliative care team. A SWOT analysis was conducted to identify readiness for implementing palliative care. Results: Twelve responses were returned from the 15 primary care providers surveyed (80%). The majority (75%) felt confident in their knowledge of palliative care and that their patients would benefit from palliative care. They also felt that palliative should be available as an inpatient and an outpatient service. Six (50%) reported that being unable to spend time on palliative care resulted in job dissatisfaction. One (8%) expressed interest in becoming a palliative care provider, and three (25%) wanted to know more. The Summary of Estimated Financial Impact: Direct Cost Savings data indicated a potential savings of more than $600,000 to the facility annually. The SWOT analysis indicated that SLVH already has many resources to facilitate the implementation of a palliative care program.
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Decreasing Obesity on the Navajo Nation: Educating Providers on Food Insecurity ScreeningPurpose: The purpose of this quality improvement (QI) project was to improve the food insecurity screening process for all adult-primary care patients, by educating providers on food insecurity, assessing for household food quality and sufficiency, identifying the barriers that cause food insecurity, and identifying the interventions needed to increase access to healthy food. Background: Patients living in rural communities throughout the Navajo Nation continue to be negatively impacted by the lack of resources and various social determinants of health. Patients who screen positive for food insecurity are more likely to be diagnosed with chronic illnesses, such as obesity, hypertension, cardiovascular disease, diabetes, non-alcoholic fatty liver disease, and cancer. Educating providers on adequate food insecurity screening tools and the consequences of food insecurity can reveal the challenges that residents of the Navajo Nation face when it comes to accessing healthy and nutritious foods. Methods: The study was comprised of a 22-question pretest, a live educational presentation, and a 14-question posttest. The pretest was distributed to participants, prior to the intervention, to determine the participant’s baseline knowledge of food insecurity screening. Next, a live educational presentation was conducted at the Primary Care Clinic weekly staff meeting on October 17, 2024. Lastly, the participants completed the posttest to evaluate the effectiveness of the educational material. The pre- and posttests included questions about food insecurity, screening, and the readiness of the participant to implement food security screening and provide education to the patient. Results: A total of 44 staff members from the Tséhootsooí Medical Center Primary Care Clinic participated in the project. After attending the educational presentation on food insecurity and decreasing obesity on the Navajo Nation and completing the pre- and post- surveys, all participants (100%) reported an increase in knowledge about food insecurity. Conclusions: This project successfully increased participants’ knowledge of food insecurity and their ability to correctly enter medical nutrition referrals. The interventions introduced the ongoing issues affecting the patients throughout the Navajo Nation. Providers need to utilize evidence-based practice and the knowledge gained from this QI project to improve the food insecurity process and help patients get the resources they need.
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Perspectives of Teacher and Educational Leaders About E-Learning Platform Experience in Jimmy Sunshine Elementary School in Mimi Rose School DistrictThis qualitative case study investigates some views of teacher and educational leaders using the implementation and effectiveness of the e-learning platform in teaching in an elementary school setting. The research was conducted at Jimmy Sunshine Elementary School within the Mimi Rose School District in Southern Arizona. The study would dwell on how teachers of the elementary level are using the e-learning platform, the perceived benefits and challenges, and the overall effect on teaching and learning. Data collection involved triangulation of methods: analysis of documents (lesson plans), classroom observations, and semi-structured interviews with a teacher, the principal, and two assistant principals. The Technological Pedagogical Content Knowledge (TPACK) framework was used to analyze the way teachers integrated technology, pedagogy, and content into their teaching practices. Findings revealed that e-learning platforms were perceived as valuable tools for enhancing instruction, promoting student engagement, and facilitating individualized learning. The TPACK framework analysis indicated that effective technology integration was contingent upon teachers' pedagogical content knowledge, technological content knowledge, and technological pedagogical knowledge. However, it also highlighted some challenges that needed to be addressed: the continuing professional development for teachers to use technology effectively, the issue of the digital divide in terms of equal access for all students, and the need for e-learning platforms to be aligned with curriculum standards.
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Increasing Compliance with Annual Preventative Visits in Adults Ages 18-64 with MedicaidPurpose. The purpose of this quality improvement (QI) project was to increase compliance with annual preventative visits in adults ages 18 to 64 with Medicaid by identifying facilitators and barriers. Background. Annual preventative visits increase preventative care uptake and the detection and treatment of chronic disease (Liss et al., 2024). However, completion rates for annual preventative visits have been suboptimal, especially for those with Medicaid or without health insurance and between the age range of 18 to 64. Increasing compliance with annual preventative visits is essential to reduce the burden of chronic disease in the U.S. This also aligns with an objective of Healthy People 2030, which is to “Increase the proportion of adults who get recommended evidence-based preventative health care (U.S. Department of Health and Human Services, n.d.). Methods. Patients at the Ginger Ryan Clinic (GRC) who met inclusion criteria (between the ages of 18 and 64 and having Medicaid insurance) were asked to complete a survey to identify facilitators and barriers to compliance with annual preventative visits. The principal investigator (PI) wrote the ten survey questions based on facilitators and barriers to preventative care identified in the literature review. The patient service representatives (PSRs) distributed surveys to patients who met the inclusion criteria and were willing to participate in the waiting room at check-in for appointments. Surveys were distributed over two weeks. Results. A total of 23 surveys were collected. The surveys successfully identified facilitators and barriers to compliance with annual preventative visits. These included age, gender, having a usual source of care, frequency of visits to the clinic per year, health beliefs, and reminders to schedule. Conclusions. Identifying facilitators and barriers to compliance with annual preventative visits is a vital first step in increasing compliance. While this project did identify some facilitators and barriers, future research and PDSA cycles are needed to strengthen the available evidence and define what facilitators and barriers should be focused on.
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Enhancing Provider Awareness and Screening for Loneliness in Rural Community Mental Health SettingsPurpose: The purpose of this quality improvement (QI) project was to assess whether an educational intervention on loneliness and the application of the UCLA Loneliness Scale would improve mental health providers’ knowledge, confidence, and ability to screen for loneliness in a rural mental health setting.Background: Loneliness has been recognized as a significant contributor to poor mental and physical health outcomes, particularly in rural populations, where geographic and social isolation exacerbate the issue. Despite its importance, loneliness is often under-addressed in clinical practice. Mental health providers face challenges, including limited resources, lack of confidence in screening techniques, and minimal training on validated tools like the UCLA Loneliness Scale. Addressing these gaps could enhance providers’ capability to identify and support patients experiencing loneliness, ultimately improving patient outcomes. Methods: This project employed a pretest-posttest design to measure changes in provider knowledge, confidence, and comfort levels related to loneliness screening. An asynchronous educational presentation, hosted on YouTube, introduced the importance of loneliness screening, the health impacts of loneliness, and practical guidance on using the UCLA Loneliness Scale. Eight of the 28 invited mental health providers completed both the pretest and posttest, with data collected through Google Forms. Results: Post-intervention results indicated significant improvements in provider confidence and knowledge. Pretest responses showed only one provider felt “very confident” in loneliness screening; posttest results showed this increased to three providers, from 12.5% to 37.5%. Familiarity with the UCLA Loneliness Scale also improved, with no providers initially rating themselves as “very knowledgeable,” but post-intervention, three providers (37.5%) rated their knowledge at this level. Additionally, the proportion of providers who felt comfortable discussing loneliness rose from 37.5% to 62.5%. Conclusions: The educational intervention effectively enhanced mental health providers' knowledge, confidence, and comfort in screening for loneliness. By equipping providers with the tools and knowledge to address loneliness, this project highlights a potential pathway for improving patient-centered care in rural mental health settings. Further research is recommended to explore long-term impacts and address ongoing barriers, such as time constraints and resource limitations, to integrate loneliness screening into routine practice fully.
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Improving Healthcare Provider Knowledge of Depression Screening in AdolescentsPurpose: The objective of this project was to increase provider knowledge and awareness of the Patient Health Questionnaire modified for Adolescents (PHQ-A) which is a validated but more age-appropriate depression screening tool for adolescents in a pediatric primary care setting. Background: The rates of adolescent mental health disorders, including depression and suicide, are increasing at an alarming rate. Although there are screening methods in place, many patients continue to go undiagnosed and untreated. One issue might be the tool used to screen for depression. If a depression screening tool was developed and validated on adults, then it is not the best tool for the pediatric populations. An age-appropriate screening tool, like the PHQ-A, can be used to screen for mental health related symptoms. Methods: A literature synthesis was utilized in planning the intervention. Methods include a 10-15 minute in person educational session in which the DNP student presented on the benefits of using the PHQ-A over the Patient Health Questionnaire-2 (PHQ-2) and Patient Health Questionnaire-9 (PHQ-9), which are already being utilized at Arbor Medical Partners Pediatrics. An educational based handout was used to guide the presentation. A survey was provided to the participants afterwards that addressed if knowledge and awareness was gained on the topic in addition to feedback about the educational offering itself. Results: Surveys from eight participants were obtained. Medical assistants and providers felt as though the education was helpful because the statistics provided justified the use of the PHQ-A, the information gained could be used to inform families, and the important role that healthcare providers play in depression screening in adolescents was emphasized. All participants agreed that they would be likely to adopt the PHQ-A into their future practice as well as be supportive of the clinic adopting it. Suggestions on how to improve the educational offering and how it was presented were minimal. Conclusions: The results demonstrated a positive response to the educational offering and the PHQ-A itself. Further PDSA cycles need to be completed to work on ways to accomplish adopting the PHQ-A into practice at Arbor Medical Partners Pediatrics.
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Evidence-Based Education to Enhance Triage Nurses’ Fever Management GuidancePurpose: The purpose of this Doctor of Nursing Practice (DNP) quality improvement project is to present a 15-minute presentation with pre- and post-surveys to review and add to the knowledge and confidence of triage nurses in advising caregivers of a fevering child. Background: Many parents worry excessively about fevers in children, leading to unnecessary visits to healthcare providers and overtreatment with medication. These concerns can be reduced through education provided by triage nurses. By providing parents with accurate information about fever management and when to seek medical attention, triage nurses can help reduce unnecessary healthcare utilization and improve patient outcomes. Methods: This quality improvement project used a quantitative quasi-experimental method with a convenience sample of a group of triage nurses at a midsized suburban city in central Utah. Pre and post-surveys with an educational presentation were utilized. With descriptive statistics applied the change in knowledge and confidence level were examined. Results: After the intervention, triage nurses demonstrated more consistent and accurate understanding of fever management principles, and significant increase in confidence in providing advice to caregivers of fevering children. Conclusions: This DNP project aimed to improve triage nurses' knowledge and confidence in advising parents of children with fevers. After watching an educational video, the nurses demonstrated significant improvement in both knowledge and confidence. This suggests that targeted educational interventions can empower triage nurses to provide better guidance to parents, potentially reducing unnecessary healthcare visits.
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Obesity and Depression in a Primary Care SettingPurpose: This quality improvement (QI) project assessed the impact of a 30-minute educational session for primary care providers (PCPs) on their readiness, willingness, and confidence to conduct mental health screenings using the Patient Health Questionnaire- 2 (PHQ-2) tool in overweight and obese patients during weight management consultations. Background: Obesity and depression often co-occur, with obesity increasing the risk of developing depression and vice versa. Mental health screenings are not consistently integrated into obesity management in clinical settings. Early identification of depression through validated tools like the PHQ-2 could lead to more comprehensive care and better health outcomes for obese patients. Methods: The QI project involved a 30-minute educational session for providers at a concierge medicine clinic in Surprise, Arizona. Post-pre surveys were administered to assess changes in confidence, knowledge, and willingness to screen for depression. PHQ-2 screening utilization were tracked for 14 days post-intervention and compared to six months of baseline data. Results: Findings found PHQ-2 screenings increased by 80%, over a similar 14-day period. All of the participants reported improved confidence in conducting mental health assessments. Chart reviews indicated that 90% of the PHQ-2 screenings were completed and documented in the electronic health records. Conclusions: Provider confidence and the frequency of PHQ-2 utilization improved during weight management consultations. Brief, targeted educational interventions can effectively enhance the integration of mental health screenings into caring for obese patients, addressing the interconnected issues of obesity and depression. The project supports the need for continued education and integration of mental health tools to improve comprehensive care delivery.
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Education on Cannabinoid Hyperemesis Syndrome To Improve Psychiatric Provider KnowledgeBackground: Cannabis use has increased significantly in recent decades. Patients may develop cannabinoid hyperemesis syndrome (CHS) after months or years of sustained heavy cannabis consumption, which is characterized by cyclical nausea, vomiting, and abdominal pain. Providers are frequently unaware of this condition and would benefit from education to improve their knowledge and ability to care for patients who develop it. Purpose: This quality improvement project aimed to increase objective knowledge about thecause, symptoms, signs, and management of CHS through a one-page electronic handout for psychiatric providers at El Rio Cherrybell. This project also sought to learn whether the educational intervention increased provider comfort in discussing CHS, familiarity, and confidence in its assessment and management. Methods: Participants were emailed an educational handout on CHS, which utilized Information Processing Theory (IPT) in its design. Within the same email, the project coordinator provided pre-testing and post-testing links to assess provider baseline knowledge and subjective confidence on the topic and how it changes after reading the one-page document. Results: Out of four providers contacted via email, two participated and completed all testing asynchronously. The project coordinator found that the providers were already familiar with the topic, as the aggregated correct response rate was 83% on pre-testing. On post-testing, the aggregated correct response rate increased to 100%. Using a Likert-like scale that ranged from one to five, with one indicating strongly disagree and five indicating strongly agree, the project coordinator found that the average response to the question, “I am familiar with CHS and am comfortable discussing it with patients,” increased from 4.5 to 5, and for the question, “I am confident in assessing and treating patients with CHS,” the average response increased from 4 to 4.5. Conclusions: Providing an educational handout to psychiatric providers increased objectiveknowledge regarding CHS, their self-perceived familiarity with the topic, their comfort in discussing it with patients, and their confidence in assessing and managing it.
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A Quality Improvement Project: Reducing Stigma of Opioid Addiction and Its Treatment Through Education InitiativesPurpose: Medications for opioid use disorder (MOUD) are considered the standard of care for substance use disorder (SUD); however, the literature reveals a significant underutilization of this treatment. The medications work to reduce acute withdrawal symptoms and opioid cravings to prevent hazardous drug use, subsequently resulting in a reduction in overdose and secondary diseases and injuries related to high-risk behavior when under the influence of substances. A quality improvement project was designed to educate staff at a local prison on addiction and treatment involving MOUD in the context of a recently implemented program including buprenorphine. Background: OUD is a prevalent issue amongst those incarcerated, with high rates of return to use and overdose upon reentry to the community. MOUD/MAT programs have increased in correctional settings but still fall short of meeting the current needs of this population. Stigma surrounding addiction can lead to delayed access in treatment and plays a role in an individual’s continued use. Methods: Both clinical and correctional staff were recruited through email with participation occurring over the course of 10 days. Some 23 participants completed the pre- and post-surveys in their entirety and were included in the results analysis. Results: There was evidence of improved knowledge regarding the statistics and neurobiology of addiction as well as influential factors of addiction related to the social determinants of health model. The open-ended questions provided staff the opportunity to share their perceived barriers in administering MOUD to inmates which varied in response, from no concerns or non-applicability to their job function to concerns with the safety of the program related to diversion and subsequent misuse of the medication. Conclusion: The educational intervention provided staff at a local prison with evidence-based information surrounding the use of MOUD. Based on staff feedback, there may be an opportunity for further exploration of potential contributing factors in medication diversion. The literature highlights diversion as a legitimate concern, however, protocols exist in prevention strategies including staff administration process, and route of medication being considered for the uniqueness of the correctional facility needs.
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Enhancing Patient Education for Postpartum Depression in a Pediatric PracticeBackground: Maternal mental health and mortality is a growing concern nationwide. The American Academy of Pediatrics (AAP) now recommends routine, standardized postpartum depression (PPD) screening at well-child visits (Wells, 2023). However, there are still inconsistencies in screening processes, and over 50% of cases remain undetected. Although highly treatable, only 12-30% of identified women receive adequate PPD treatment and services (Cattoni et al., 2022). Due to the detrimental effects of PPD, it is essential to ensure proper screening, education, identification, and interventions are in place.Purpose: The purpose of this quality improvement (QI) project was to enhance patient knowledge of PPD and local resources for further evaluation and support through the development and implementation of a patient handout. Methods: Women within one year postpartum attending well-child visits at a pediatric primary care clinic in Queen Creek, Arizona were invited to evaluate the effectiveness of an educational brochure. This handout was designed by the project investigator (PI) in partnership with providers at the pediatric practice. It included information on PPD, its impact and significance, purpose of screening, and available resources. A post-intervention survey was conducted to evaluate perceptions, patient satisfaction, and its effectiveness in enhancing education on PPD. The target sample was 30 surveys. Results were analyzed using descriptive statistics and free-text responses were summarized. Results: After 2 weeks of implementation, 20 women agreed to participate. A Likert Scale was used to analyze survey questions, and answers were interpreted as a rating from 1 (strongly disagree) to 5 (strongly agree). Average agreement scores were calculated and used to evaluate results. Overall, after reviewing the brochure, women felt comfortable discussing PPD with their child’s provider (4.53) and had a better understanding of PPD (4.21). Patient satisfaction with the brochure was also high, and respondents found listed resources helpful (4.79). Although most women reported completing PPD screenings prior to their appointments, several perceived barriers to screening were still identified. Conclusions: This QI project suggested that the use of a patient educational brochure was effective for enhancing patient knowledge of PPD and available local resources at a pediatric clinic in Queen Creek, Arizona.
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The Role of Wildtype and Fusion FET Proteins in Transcription Related R-Loop RegulationCo-transcriptional R-loops form when nascent RNA transcripts base pairs with the template DNA strand, displacing the non-template DNA strand. Initially considered a transcriptional byproduct with potential implications for genomic integrity, recent studies highlight the regulatory roles of R-loops. The FET family proteins (FUS, EWSR1, and TAF15) have emerged as significant players in R-loop-mediated transcriptional regulation. This study investigates the mechanisms by which FUS and EWSR1 contribute to transcriptional regulation and global R-loop dynamics. Furthermore, we explore the implications of translocation events leading to the expression of the EWS-FLI1 fusion protein, a hallmark of Ewing Sarcoma present in more than 85% of patients. First, we employed electrophoretic mobility shift assays (EMSA) to show that EWSR1 directly interacts with R-loops through DNA fork regions. The specificity of this interaction is mediated by the RGG1-RRM-RGG2 domains, while the RGG2-ZnF-RGG3 domains contribute to its affinity. Second, we found that both wildtype EWSR1 and the fusion EWS-FLI1 protein interact with RNAPII in large membraneless organelles, where they regulate similar transcripts implicated in Ewing Sarcoma pathogenesis. Next, using in vitro transcription assays, we demonstrate that FUS promotes T7 polymerase-mediated transcription by binding to RNA, thereby inhibiting R- loop formation. This finding is further supported by FUS knockdown in HEK293 cells which leads to the accumulation of R-loops. Lastly, through quantitative mass spectrometry proteomics, we found that aberrant R-loop accumulation disrupts mitochondrial, mitotic, and transport processes in A673 Ewing Sarcoma cells.
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Pressure Anisotropy-Driven Instabilities in Solar and Astrophysical PlasmasPressure anisotropy is a feature found in plasmas that are preferentially heated parallel or perpendicular to the local magnetic field by processes such as expansion or turbulent dissipation. This anisotropy can drive instabilities that affect energy transport and plasma evolution in a variety of solar and astrophysical contexts. In this dissertation, we investigate pressure anisotropy-driven instabilities that are observed in the solar wind and operate in other weakly collisional plasmas. We first provide a broad overview of these instabilities, including a description of current observations and the analytic and numeric methods used to analyze their growth and saturation. We then leverage linear kinetic theory to investigate the impact of distribution function structure on the stability of Alfvén ion-cyclotron modes. Solar wind proton velocity distribution functions extracted from Wind spacecraft observations of the solar wind are used to evaluate the efficacy of existing simplified models in predicting stable or unstable behavior of these modes. While kinetic theory can provide detailed information on particle behavior, including resonant wave-particle interactions, it can pose significant computational challenges to use this prescription to run high-resolution simulations of plasmas. We utilize a 10-moment, multi-fluid model to run nonlinear simulations that incorporate sufficient physics to drive and saturate firehose instabilities. The fidelity of these simulations in modeling real space plasma systems is increased by proceeding from 1D simulations to 2D simulations that can capture both the parallel and oblique firehose modes. As part of this work, we develop the expanding box model within the 10-moment, multi-fluid computational framework. With preliminary test cases validating the implementation of the 10-moment expanding box model, we anticipate that this model will allow self-consistent modeling of plasma expansion. Utilizing solar wind or astrophysical plasma parameters, the 10-moment expanding box can explore a variety of plasma phenomena, including the evolution of turbulence and instabilities in these systems.
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Promoting Early Recognition and Management of Valley Fever in Primary Care SettingsPURPOSE. This project was designed to strengthen primary care provider (PCP) knowledge and confidence in Valley fever diagnosis, treatment, and specialty-referral requirements at a Southern Arizona rural community health organization.BACKGROUND. Coccidioidomycosis (i.e., Valley fever) is a fungal infection acquired by inhaling spores located in the dust of endemic regions. Southern Arizona has the highest incidence of the disease in the nation, with Maricopa, Pima, and Pinal Counties accounting for over half of all cases in the United States. Despite the fact that Valley fever is responsible for one-third of all pneumonia cases diagnosed in Southern Arizona, only 13% of Arizona PCPs appropriately test for the disease. Patients experience on average a one-month delay for diagnosis, and more than 80% of cases are initially misdiagnosed. This delay to diagnosis leads to increased healthcare costs, increased incidence of complications, and delayed specialist referral for high-risk patients. METHODS. The multilevel intervention design included a 30-minute, synchronous provider education session delivered via Microsoft TEAMS. Education content was developed from Infectious Disease Society of America (IDSA) clinical practice guidelines, a 2017 CDC Valley Fever PCP training video, and the Valley Fever Center for Excellence (VFCE) training manual for PCPs. A pocket-sized handbook and printable flowchart of the educational material was also provided. Evaluation was accomplished with a post-pre survey examining provider knowledge, attitudes, and practices related to Valley fever diagnosis and management. A “Valley Fever Champion” was selected from among participating PCPs to provide quarterly educational emails and attend the annual VFCE meeting. RESULTS. Of the 31 providers in attendance, 19 completed the post-education evaluation survey. Statistically significant improvements were seen in provider confidence in ability to diagnose (p=.001) and treat (p=.011) Valley fever, and knowledge of lab testing options (p=.031). Modest improvements were gained in knowledge of vaccine availability and health department notification requirements. Notably, among providers who obtained their clinical degree in Arizona, only 20% reported receiving prior education on Valley fever. CONCLUSIONS. This project demonstrates an effective model for providing Valley fever training to Arizona PCPs and connecting them with local specialists and resources from organizations such as the VFCE.