Human Tandem Repeats in Breast Cancer Progression
| dc.contributor.author | Kinnard, Krista | |
| dc.creator | Kinnard, Krista | en_US |
| dc.date.accessioned | 2011-10-19T18:22:37Z | |
| dc.date.available | 2011-10-19T18:22:37Z | |
| dc.date.issued | 2010-05 | |
| dc.identifier.citation | Kinnard, Krista. (2010). Human Tandem Repeats in Breast Cancer Progression (Bachelor's thesis, University of Arizona, Tucson, USA). | |
| dc.identifier.uri | http://hdl.handle.net/10150/146036 | |
| dc.description.abstract | A tandemly-repeated sequence of DNA located approximately 1kb upstream of HIC1 has been identified which appears to regulate the expression of this important tumor suppressor gene. Loss of HIC1 expression in tumors, either by deletion or hypermethylation, has previously been shown to correlate with a more severe prognosis in multiple cancers. Initial data show that larger alleles of this tandem repeat do not influence incidence of disease but do appear to correspond with a heritable predisposition to more aggressive cancers, represented by earlier onset and increased metastasis. This study hypothesizes that there may be a connection between these more aggressive types of cancer but also with the deleterious BRCA mutation. | |
| dc.language.iso | en | en_US |
| dc.publisher | The University of Arizona. | en_US |
| dc.rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. | en_US |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.title | Human Tandem Repeats in Breast Cancer Progression | en_US |
| dc.type | text | en_US |
| dc.type | Electronic Thesis | en_US |
| thesis.degree.grantor | University of Arizona | en_US |
| thesis.degree.level | bachelors | en_US |
| thesis.degree.discipline | Honors College | en_US |
| thesis.degree.discipline | Molecular and Cellular Biology | en_US |
| thesis.degree.name | B.S. | en_US |
| refterms.dateFOA | 2018-07-13T07:43:46Z | |
| html.description.abstract | A tandemly-repeated sequence of DNA located approximately 1kb upstream of HIC1 has been identified which appears to regulate the expression of this important tumor suppressor gene. Loss of HIC1 expression in tumors, either by deletion or hypermethylation, has previously been shown to correlate with a more severe prognosis in multiple cancers. Initial data show that larger alleles of this tandem repeat do not influence incidence of disease but do appear to correspond with a heritable predisposition to more aggressive cancers, represented by earlier onset and increased metastasis. This study hypothesizes that there may be a connection between these more aggressive types of cancer but also with the deleterious BRCA mutation. |
