Bile Acids to Predict the Developments of Neonatal Necrotizing Enterocolitis

Abstract

This honors thesis analyzes the methodology and results of ongoing research on the potential use of bile acid concentrations in neonatal stool to be used as an indicator for the onset of the disease necrotizing enterocolitis (NEC). NEC is a serious complication in a premature infant with the potential for death. Twenty-two patients were enrolled in the study over the period of eight months, however, no patient developed NEC. Control patients were analyzed for trends in bile acid concentrations. Elevation of in bile acid concentration were seen following each feeding. Previous inclinations were also proven in regards to that mother's milk is more easily digested and remains a more nutritionally sound form of feeding than formula milk.