Show simple item record

dc.contributor.advisorYalkowsky, Samuel H.en_US
dc.contributor.authorMishra, Dinesh Shyamdeo.
dc.creatorMishra, Dinesh Shyamdeo.en_US
dc.date.accessioned2011-10-31T17:14:59Z
dc.date.available2011-10-31T17:14:59Z
dc.date.issued1989en_US
dc.identifier.urihttp://hdl.handle.net/10150/184667
dc.description.abstractSolubility of drugs in non-aqueous systems is very important in understanding the partitioning and transport behavior. The present study was undertaken to evaluate the entropic and enthalpic contribution to activity coefficient of organic compounds (polycyclic aromatic hydrocarbons, aliphatic acids, aliphatic alcohols etc.) in non-aqueous solvents. The activity coefficient can be written as: ln γ₁ = ln γ₁ᶜ + ln γ₁ʳ where superscript "c" and "r" denote entropic (combinatorial) and enthalpic contribution respectively. We selected three solvent systems: benzene, triolein and octanol. The different models considered in this study were Flory-Huggins, Scatchard-Hildebrand, UNIQUAC combinatorial and UNIFAC residual. A combination of Flory-Huggins and Scatchard-Hildebrand which accounts for both the entropic and enthalpic effects gives the best predictions in all the solvents considered.
dc.language.isoenen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectOrganic compounds -- Solubility.en_US
dc.subjectSolubility -- Mathematical models.en_US
dc.subjectSolutions (Pharmacy)en_US
dc.titleSolubility of organic compounds in nonaqueous systems.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.identifier.oclc702370110en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.leveldoctoralen_US
dc.identifier.proquest8915976en_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.namePh.D.en_US
refterms.dateFOA2018-08-19T04:37:02Z
html.description.abstractSolubility of drugs in non-aqueous systems is very important in understanding the partitioning and transport behavior. The present study was undertaken to evaluate the entropic and enthalpic contribution to activity coefficient of organic compounds (polycyclic aromatic hydrocarbons, aliphatic acids, aliphatic alcohols etc.) in non-aqueous solvents. The activity coefficient can be written as: ln γ₁ = ln γ₁ᶜ + ln γ₁ʳ where superscript "c" and "r" denote entropic (combinatorial) and enthalpic contribution respectively. We selected three solvent systems: benzene, triolein and octanol. The different models considered in this study were Flory-Huggins, Scatchard-Hildebrand, UNIQUAC combinatorial and UNIFAC residual. A combination of Flory-Huggins and Scatchard-Hildebrand which accounts for both the entropic and enthalpic effects gives the best predictions in all the solvents considered.


Files in this item

Thumbnail
Name:
azu_td_8915976_sip1_m.pdf
Size:
2.625Mb
Format:
PDF
Description:
azu_td_8915976_sip1_m.pdf

This item appears in the following Collection(s)

Show simple item record