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dc.contributor.advisorBinkiewicz, Annaen_US
dc.contributor.authorPlante, Elena Margaret.
dc.creatorPlante, Elena Margaret.en_US
dc.date.accessioned2011-10-31T17:28:48Z
dc.date.available2011-10-31T17:28:48Z
dc.date.issued1990en_US
dc.identifier.urihttp://hdl.handle.net/10150/185140
dc.description.abstractFour families that include a specifically language-impaired (SLI) boy served as subjects of this study. The background and behavioral characteristics of these subjects indicated that a majority of the parents and siblings of the language-disordered boys also experienced difficulty with speech, language, and academic skills. This information was paired with neuroanatomical data obtained through quantitative analysis of magnetic resonance imaging (MRI) scans. Atypical perisylvian asymmetries, a characteristic previously associated with developmental language disorders in children, were documented in the majority of the parents of language-disordered boys (p < .05). Atypical perisylvian asymmetries in these parents were closely associated (p = .84) with a positive history for difficulty with speech, language, or academic skills. The presence of these behavioral and biological characteristics in the parents of SLI boys is consistent with the hypothesis that language disorders are biologically transmittable. Siblings in one of the four families had documented impairments of language skills. These subjects also had atypical perisylvian asymmetries. An additional sibling from a second family had atypical perisylvian asymmetries. The presence of atypical perisylvian asymmetries in multiple family members suggests that atypical perisylvian asymmetries reflect biological factors that place some families at risk for language impairment. The pattern of atypical perisylvian asymmetries documented in this study reflect a probable disturbance of prenatal brain development. Measurement of cerebral areas in addition to the perisylvian demonstrated that the hypothesized effects on the developing brain were bilateral and widespread. These features are in contrast to the neuroanatomical profile typically associated with cases of acquired language disorder, which typically result from damage to the left perisylvian area in a premorbidly normal brain.
dc.language.isoenen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectBiologyen_US
dc.subjectEducation.en_US
dc.titleCerebral configurations among the parents and siblings of language-disordered boys.en_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
dc.identifier.oclc708653935en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.leveldoctoralen_US
dc.contributor.committeememberLauter, Judithen_US
dc.contributor.committeememberGlattke, Theodoreen_US
dc.contributor.committeememberRapcsak, Stevenen_US
dc.identifier.proquest9100557en_US
thesis.degree.disciplineSpeech and Hearing Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.namePh.D.en_US
refterms.dateFOA2018-06-13T07:38:21Z
html.description.abstractFour families that include a specifically language-impaired (SLI) boy served as subjects of this study. The background and behavioral characteristics of these subjects indicated that a majority of the parents and siblings of the language-disordered boys also experienced difficulty with speech, language, and academic skills. This information was paired with neuroanatomical data obtained through quantitative analysis of magnetic resonance imaging (MRI) scans. Atypical perisylvian asymmetries, a characteristic previously associated with developmental language disorders in children, were documented in the majority of the parents of language-disordered boys (p < .05). Atypical perisylvian asymmetries in these parents were closely associated (p = .84) with a positive history for difficulty with speech, language, or academic skills. The presence of these behavioral and biological characteristics in the parents of SLI boys is consistent with the hypothesis that language disorders are biologically transmittable. Siblings in one of the four families had documented impairments of language skills. These subjects also had atypical perisylvian asymmetries. An additional sibling from a second family had atypical perisylvian asymmetries. The presence of atypical perisylvian asymmetries in multiple family members suggests that atypical perisylvian asymmetries reflect biological factors that place some families at risk for language impairment. The pattern of atypical perisylvian asymmetries documented in this study reflect a probable disturbance of prenatal brain development. Measurement of cerebral areas in addition to the perisylvian demonstrated that the hypothesized effects on the developing brain were bilateral and widespread. These features are in contrast to the neuroanatomical profile typically associated with cases of acquired language disorder, which typically result from damage to the left perisylvian area in a premorbidly normal brain.


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