PROGRESS TOWARDS A SYNTHESIS OF DEOXYBOUVARDIN AND ANALOGUES; NEW SYNTHETIC METHODS.
Name:
azu_td_8505232_sip1_m.pdf
Size:
1.468Mb
Format:
PDF
Description:
azu_td_8505232_sip1_m.pdf
Publisher
The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
This work involved synthetic approaches to the anti-tumor agent deoxybouvardin. Numerous reactions were explored in an attempt to build an amino acid from an aromatic aldehyde under mild conditions. From these reactions new and useful synthetic methods have been discovered for making α-acylamino alcohols and unsymmetrical imides. Some dehydroamino acids were successfully prepared from aromatic aldehydes and an N-acylphosphorylglycine ester. Progress towards a synthesis of 5- η-thiodeoxybouvardin will also be discussed.Type
textDissertation-Reproduction (electronic)
Degree Name
Ph.D.Degree Level
doctoralDegree Program
ChemistryGraduate College