PROGRESS TOWARDS A SYNTHESIS OF DEOXYBOUVARDIN AND ANALOGUES; NEW SYNTHETIC METHODS.
AuthorJANDA, KIM DAVID.
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PublisherThe University of Arizona.
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AbstractThis work involved synthetic approaches to the anti-tumor agent deoxybouvardin. Numerous reactions were explored in an attempt to build an amino acid from an aromatic aldehyde under mild conditions. From these reactions new and useful synthetic methods have been discovered for making α-acylamino alcohols and unsymmetrical imides. Some dehydroamino acids were successfully prepared from aromatic aldehydes and an N-acylphosphorylglycine ester. Progress towards a synthesis of 5- η-thiodeoxybouvardin will also be discussed.