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    The Effect of Satellite Cells on Angiogenesis

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    Author
    Johnson, Rebecca Marie
    Issue Date
    2007
    Committee Chair
    Allen, Ronald E.
    
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Research for this thesis was conducted to study the mechanism by which satellite cells affect angiogenesis via hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF). We found that satellite cells exposed to hypoxia and cobalt chloride (CoCl2) had increased HIF-1 activity, greater VEGF gene expression, and higher levels of VEGF protein secreted into conditioned medium, when compared to satellite cells cultured in normoxia. The biological role of VEGF protein in satellite cell-mediated angiogenesis was observed when the growth of microvascular sprouts in satellite cell conditioned medium was inhibited by the addition of VEGF soluble receptors. This inhibition could be reversed when recombinant VEGF protein was added. Taken together, these data suggest that satellite cells mediate angiogenesis through the secretion of VEGF protein, and VEGF secretion can be increased upon exposure to a hypoxic environment.
    Type
    text
    Electronic Thesis
    Degree Name
    MS
    Degree Level
    masters
    Degree Program
    Animal Sciences
    Graduate College
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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