THE ROLE OF DIFFERENT ADIPOCYTE SIZE POPULATIONS IN THE MEDIATION OF OBESITY-RELATED INSULIN RESISTANCE AND INFLAMMATION
Committee ChairTsao, Tsu-Shuen
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PublisherThe University of Arizona.
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AbstractInsulin resistance, the cause of type 2 diabetes mellitus, is intimately linked to the dysregulation of adipose tissue. Recent decades have witnessed the discovery and characterization of numerous hormones produced by adipocytes, including leptin, adiponectin and resistin, underscoring the endocrine functions of adipose tissue. To better understand the role of the adipocyte in the mediation of obesity-related insulin resistance and inflammation, this study has optimized the primary adipocyte isolation technique to minimize inflammation inherent to the isolation procedure and has analyzed adiponectin levels and insulin sensitivities of various adipocyte size populations both in vitro and ex vivo.The data described herein suggest that cell size plays an important, but not solitary, role in the regulation of insulin action and adiponectin production. It is possible that obesity-related insulin resistance is associated with the failure of a population of small adipocytes to expand and produce the insulin sensitizing protein hormone, adiponectin.
Degree ProgramMolecular & Cellular Biology