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    Ultrathin Single and Multi-Channel Fiberscopes for Biomedical Imaging

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    Author
    Kano, Angelique Lynn
    Issue Date
    2009
    Keywords
    biomedical
    coherent fiber bundle
    diffuse reflectance
    mouse esophagus
    single channel
    ultrathin fiberscope
    Advisor
    Gmitro, Arthur F.
    Committee Chair
    Gmitro, Arthur F.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Ultrathin fiberscopes typically have an imaging channel and an illumination channeland are available in diameters ranging from 0.5 mm to 2.5 mm. The minimum diam-eter can be reduced by combining the illumination and imaging paths into a singlefiberoptic channel. Constructing a single channel fiberscope requires a technique ofilluminating the tissue, while minimizing the Fresnel reflections and scatter withinthe common illumination and detection channel.A single channel fiberscope should image diffusely reflected light from tissue illu-minated with light filtered for the visible wavelength range (450 - 650 nm). Simplycombining the illumination and collection paths via a beamsplitter results in a lowobject to background signal ratio. The low contrast image is due to a low collectionefficiency of light from the ob ject as well as a high background signal from the Fresnelreflection at the proximal surface of the fiber bundle, where the illumination enters thefiber bundle. The focus of the dissertation is the investigation of methods to reducethe background signal from the proximal surface of the fiber bundle. Three systemswere tested. The first system uses a coherent fiber bundle with an AR-coating on theproximal face. The second system incorporates crossed polarizers into the light path.In addition, a technique was developed, whereby a portion of the image numericalaperture is devoted to illumination and a portion to image signal detection. Thistechnique is called numerical aperture sharing (NA sharing).This dissertation presents the design, construction, testing, and comparison ofthe three single channel fiberscopes. In addition, preliminary results of a study aimedat the usefulness of broadband diffuse reflectance imaging for the identification andtracking of disease progression in mouse esophagus are presented.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Optical Sciences
    Graduate College
    Degree Grantor
    University of Arizona
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