Preformulation Studies on the Anticancer Drug Imexon
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azu_etd_1999_sip1_m.pdf
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azu_etd_1999_sip1_m.pdf
Issue Date
2007Advisor
Myrdal, Paul BCommittee Chair
Myrdal, Paul BMetadata
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The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
Imexon is an aziridine-containing iminopyrrolidone that is of significant interest due to its selective growth inhibitory effect against multiple myeloma. Regrettably, administration of Imexon has proven difficult largely due to its rapid degradation in aqueous medium. The collective aim of this research was to conduct preformulation studies to characterize and understand the stability and solubility of Imexon in both aqueous and non-aqueous systems. Furthermore, these data will be utilized as rational support to create an efficacious formulation for the delivery of Imexon.Type
textElectronic Dissertation
Degree Name
PhDDegree Level
doctoralDegree Program
Pharmaceutical SciencesGraduate College