• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    The Role of Voltage Dependent Calcium Channels in Identified Motoneurons During Fictive Locomotor Behavior

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_10204_sip1_m.pdf
    Size:
    1.949Mb
    Format:
    PDF
    Description:
    azu_etd_10204_sip1_m.pdf
    Download
    Author
    Worrell, Jason Walter
    Issue Date
    2008
    Keywords
    calcium
    Drosophila
    locomotion
    motoneuron
    voltage gated
    Advisor
    Levine, Richard
    Committee Chair
    Levine, Richard
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The primary goal of this work was to examine the role of voltage-dependent Ca2+ channels in regulating the output of larval Drosophila motoneurons functioning within an intact network. To accomplish this goal, two major aims were addressed: 1. To determine whether larval Drosophila motoneurons express voltage-dependent Ca2+ channels in their central processes, and further, to determine the genes responsible. 2. To determine the role of centrally expressed voltage-dependent Ca2+ channels in the regulation of motoneuron output as motoneurons receive behaviorally relevant input from the locomotor network. To address these goals, genetic tools available in Drosophila were used along side in situ patch clamp techniques from larval motoneurons.Using whole cell voltage-clamp techniques in situ, we have shown that two identified motoneurons, aCC and RP-2, carry voltage-dependent currents recorded from the soma. Dmca1D, the L-type like channel in Drosophila, is primarily responsible for this current. Expressing Dmca1D RNAi in aCC and RP-2, as the preparation displayed fictive bouts of locomotion, caused an increase in burst duration in both RP-2 and aCC as well as an increase in the number of action potentials fired per burst. Additionally, the afterhyperpolarization between spikes was greatly reduced and spiking became less regular. This work indicates a role for Dmca1D in the processing of synaptic information in Drosophila motoneurons aCC and RP-2.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Physiological Sciences
    Graduate College
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.