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    Study of microtubule templates for fabrication of nano-interconnects

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    Author
    Yang, Yi
    Issue Date
    2005
    Keywords
    Microtubule
    interconnect
    bottom-up
    nanotechnology
    Advisor
    Deymier, Pierre A.
    Committee Chair
    Deymier, Pierre A.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Microtubules (MTs), whose basic units are a and ß tubulin proteins, are self-assembled proteinaceous filaments with nanometer scale diameters and micrometer scale lengths. Their aspect ratio, directionality, the reversibility of their assembly and their ability to be metallized by electroless plating make them good candidates to serve as templates for the fabrication of nanowires and other nanoscale devices. In addition, tubulin proteins can provide biological interactions with a naturally high specificity.Toward the goal of manufacturing MT-based metallic nanowires and networks of nanowires on a silicon wafer, I studied the influence of pH, temperature, and several biomolecules on the stability of MTs in solutions, as well as the surface effect on the dynamics of disassembly of microtubules. Secondly, I demonstrated the metallization of MTs by electroless nickel plating both in solution and on hydrophilic oxidized Si surface. After being activated by Pt, nickel coated MT surfaces during the electroless plating, with a thickness of several nanometers. Due to the different kinetics of the process, MTs metallized on the oxidized Si wafer are slightly different from MTs metallized in solutions. Finally, we explored controlled nucleation and growth of microtubules directly from a collection of g-tubulin monomers. g-tubulins bind to modified gold electrodes on a silicon wafer through an organic linker, Glutathione s-transferase, creating a g-tubulin layer for MT growth. MTs unambiguously originated from the surface-bound g-tubulin layer on the gold electrode, proving that the surface-bound g-tubulin retains its biological ability of nucleating MT growth.
    Type
    text
    Electronic Dissertation
    Degree Name
    PhD
    Degree Level
    doctoral
    Degree Program
    Materials Science & Engineering
    Graduate College
    Degree Grantor
    University of Arizona
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