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dc.contributor.advisorGmitro, Arthur F.en_US
dc.contributor.authorCorum, Curtis A.
dc.creatorCorum, Curtis A.en_US
dc.date.accessioned2011-12-06T13:57:36Z
dc.date.available2011-12-06T13:57:36Z
dc.date.issued2005en_US
dc.identifier.urihttp://hdl.handle.net/10150/195555
dc.description.abstractDistant dipolar field (DDF)-based nuclear magnetic resonance is an active research area with many fundamental properties still not well understood. Already several intriguing applications have developed, like HOMOGENIZED and IDEAL spectroscopy, that allow high resolution spectra to be obtained in inhomogeneous fields, such as in-vivo. The theoretical and experimental research in this thesis concentrates on the fundamental signal properties of DDF-based sequences in the presence of relaxation (T1 and T2) and diffusion. A general introduction to magnetic resonance phenomenon is followed by a more in depth introduction to the DDF and its effects. A novel analytical signal equation has been developed to describe the effects of T2 relaxation and diffusing spatially modulated longitudinal spins during the signal build period of an HOMOGENIZED cross peak. Diffusion of the longitudinal spins results in a lengthening of the effective dipolar demagnetization time, delaying the re-phasing of coupled anti-phase states in the quantum picture. In the classical picture the unwinding rate of spatially twisted magnetization is no longer constant, but decays exponentially with time. The expression is experimentally verified for the HOMOGENIZED spectrum of 100mM TSP in H2O at 4.7T. Equations have also been developed for the case of multiple repetition steady state 1d and 2d spectroscopic sequences with incomplete magnetization recovery, leading to spatially varying longitudinal magnetization. Experimental verification has been accomplished by imaging the profile. The equations should be found generally applicable for those interested in DDF-based spectroscopy and imaging.
dc.language.isoENen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectDDFen_US
dc.subjectiMQCen_US
dc.subjectmagnetic resonanceen_US
dc.subjectdistant dipolar fielden_US
dc.subjectintermolecular multiple quantum coherenceen_US
dc.titleNuclear Magnetic Resonance with the Distant Dipolar Fielden_US
dc.typetexten_US
dc.typeElectronic Dissertationen_US
dc.contributor.chairGmitro, Arthur F.en_US
dc.identifier.oclc137354005en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.leveldoctoralen_US
dc.contributor.committeememberBarrett, Harrison H.en_US
dc.contributor.committeememberTrouard, Theodoreen_US
dc.contributor.committeememberGalons, Jean-Phillipeen_US
dc.identifier.proquest1108en_US
thesis.degree.disciplineOptical Sciencesen_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.namePhDen_US
refterms.dateFOA2018-04-25T17:42:19Z
html.description.abstractDistant dipolar field (DDF)-based nuclear magnetic resonance is an active research area with many fundamental properties still not well understood. Already several intriguing applications have developed, like HOMOGENIZED and IDEAL spectroscopy, that allow high resolution spectra to be obtained in inhomogeneous fields, such as in-vivo. The theoretical and experimental research in this thesis concentrates on the fundamental signal properties of DDF-based sequences in the presence of relaxation (T1 and T2) and diffusion. A general introduction to magnetic resonance phenomenon is followed by a more in depth introduction to the DDF and its effects. A novel analytical signal equation has been developed to describe the effects of T2 relaxation and diffusing spatially modulated longitudinal spins during the signal build period of an HOMOGENIZED cross peak. Diffusion of the longitudinal spins results in a lengthening of the effective dipolar demagnetization time, delaying the re-phasing of coupled anti-phase states in the quantum picture. In the classical picture the unwinding rate of spatially twisted magnetization is no longer constant, but decays exponentially with time. The expression is experimentally verified for the HOMOGENIZED spectrum of 100mM TSP in H2O at 4.7T. Equations have also been developed for the case of multiple repetition steady state 1d and 2d spectroscopic sequences with incomplete magnetization recovery, leading to spatially varying longitudinal magnetization. Experimental verification has been accomplished by imaging the profile. The equations should be found generally applicable for those interested in DDF-based spectroscopy and imaging.


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