• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    REGULATION AND FUNCTION OF MARCH1: MODULATION OF IMMUNITY THROUGH UBIQUITINATION

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_11274_sip1_m.pdf
    Size:
    8.097Mb
    Format:
    PDF
    Description:
    azu_etd_11274_sip1_m.pdf
    Download
    Author
    Jabbour, Maurice E.
    Issue Date
    2010
    Advisor
    Lybarger, Lonnie P.
    Committee Chair
    Lybarger, Lonnie P.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The activation of the immune system, particularly adaptive immunity, in response to a pathogen ( e.g. viruses) relies on complex network of cell interactions including those between lymphocytes (T cells) and dendritic cells (DC). In its simplest form, the DC-mediated activation of T cells is dependent on 1) binding of antigen presenting molecules (MHC class I and class II) and their peptides to the T cell receptor and 2) interaction between costimulatory molecules (CD80 and CD86) on DC and their receptors on T cells. Together these signaling events induce an optimal T cell-dependent immune response. Viruses, including herpesviruses and poxviruses, using evolutionarily conserved ubiquitin E3 ligases, appropriate cellular ubiquitin pathways for targeting immune molecules (CD86 or MHC), thereby evading the immune response. The notion that two evolutionarily divergent virus families share conserved ubiquitin E3 ligases suggested that viruses have acquired these enzymes from the host. Indeed, a set of cellular ubiquitin E3 ligases, termed membrane-associated RING-CH proteins (MARCH), was identified in mammalian genomes. Unlike their viral orthologs, cellular E3 ligases including MARCH proteins have regulatory functions in various cellular processes and, therefore, must be tightly controlled to prevent inadvertent effects to the host. Interestingly, due to its lymphoid-restricted expression and targeting of CD86 and MHC class II levels, MARCH1 is potentially critical for the function of DC. Furthermore, since DC are essential players in the regulation of the immune response (as evident by immune deficiencies observed following ablation of DC), MARCH1 should play a critical role in immunity. Therefore, the work presented in this thesis explores the regulation and function of MARCH1 in DC.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Immunobiology
    Graduate College
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.