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AbstractIn the preemergence test, azafenidin, flufenacet, thiazopyr, isoxaben, dithiopyr, and thifensulfuron exhibited safety on cantaloupes and watermelon at rates higher than rates required for effective weed control. In the postemergence test, the margin of selectivity for melon safety and weed control was narrow for MKH-6561, flufenacet, and thifensulfuron. MKH-6561 and CGA-362622 applied preemergence did not offer any acceptable crop safety relative to the weed control that was observed. Azafenidin, thiazopyr, isoxaben, and pyrithiobac did not demonstrate adequate melon safety compared to providing good weed control.