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AbstractNicosulfuron, quinclorac, triflusulfuron, MKH-3586, pyraflufen, and tribenuron applied PREE appeared to be safe on the lettuce crops while demonstrating variable activity against weeds. Head lettuce and romaine were not as tolerant to POST herbicides compared to PREE herbicides. Sulfosulfuron, MKH-3586, rimsulfuron, ethametsulfuron and pyraflufen applied POST caused various degrees of injury on the lettuces that were less injurious than other treatments. Thifensulfuron, nicosulfuron, and quinclorac applied PREE or POST showed acceptable broccoli tolerance. Ethametsulfuron exhibited adequate safety when applied POST on broccoli. Thifensulfuron, nicosulfuron, and quinclorac applied PREE also showed spinach tolerance. Similar to head lettuce and romaine spinach was not as tolerant to POST herbicides compared to PREE herbicides.