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    Arsenic and Olfactomedin-1 Regulation of Epithelial to Mesenchymal Cell Transition (EMT) in Heart Valve Development

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    Author
    Lencinas Sanabria, Alejandro
    Issue Date
    2012
    Keywords
    Collagen Gel
    EMT checkpoint
    Heart valve formation
    Olfactomedin-1
    Pharmacology & Toxicology
    Arsenic
    Cancer metastasis
    Advisor
    Runyan, Raymond B.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    This dissertation centers on the study of epithelial to mesenchymal cell transition (EMT) in the heart model of valve development. EMT is a process used by specific cells to invade adjacent matrix in order to differentiate into a three-dimensional structure. The first section of the project includes a study on the effects of inorganic arsenic on EMT and therefore the environmental concerns produced by deleterious effects on EMT. The second section focuses on the discovery of an intrinsic regulator of EMT, olfactomedin-1 (OLFM1). The discovery of a novel regulator of EMT in the atrioventricular canal is interesting, by itself, as it allows us to better understand the intrinsic molecular regulation of EMT in valve formation of the heart. The activity of this protein, as a regulator of cell invasion, identifies an important checkpoint in EMT. Because OFLM1 is conserved across many species, including humans, it may be a common or shared regulator of all types of EMT including cancer. Therefore, OLFM1 represents a promising new target for an anti-cancer agent as well as a potential clinical inducer of EMT to repair congenital heart disease that include valve defects.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Pharmacology & Toxicology
    Degree Grantor
    University of Arizona
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