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AbstractClomazone (Command®), bensulide (Prefar®), sulfentrazone, and halosulfuron treatments applied preemergence (PREE) provided very good control of prostrate pigweed (Amaranthus blitoides), lambsquarters (Chenopodium album), and common purslane (Portulaca oleracea) at better than 90% at 5 weeks after treatment (WAT). Halosulfuron was effective in controlling all weeds better than 90% at 7 WAT Carfentrazone was not effective against most of the weeds present in the test but appeared to be safe on cantaloupe. Postemergence (POST) treatments alone did not provide acceptable control of pigweeds but controlled lambsquarters and common purslane at 2 WAT. Halosulfuron and bentazon (Basagran®) applied POST following PREE treatments controlled most of the weeds better than 90% through 7 WAT. Cantaloupe yields were highest with good weed control provided by PREE treatments followed by POST herbicide applications. Basagran at 0.50 lb /A injured cantaloupe after applications but yields were not affected compared to the untreated check. Command, sulfentrazone, and halosulfuron caused cantaloupe injury after PREE applications. Basagran caused substantial crop injury after POST applications.