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    Reward and Anxiety: From Rodent Post-Traumatic Stress to Human Psychosocial Stress

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    Author
    Corral Frias, Nadia Sarai
    Issue Date
    2012
    Keywords
    Electrophysiolgy
    Peripheral psychophysiology
    Resilience
    Reward
    Neuroscience
    Anxiety
    Dopamine
    Advisor
    Fellous, Jean-Marc
    
    Metadata
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Posttraumatic stress disorder (PTSD) is a chronic disabling condition that results from exposure to traumatic stress. However, although trauma is fairly common, PTSD will only occur in a small proportion of people. This suggests that resilience is a common response to trauma. The neurobiology underlying this adaptive response is thought to involve reward related areas as well as reward functions. This dissertation proposes that reward and reward-related areas have a role in anxiety disorders such as PTSD. This hypothesis was explored using an animal model of PTSD as well as a human mode of psychosical stress. The hypothesis that the ventral tegmental area (VTA), crucial for reward processing, is part of the neural circuitry involved in the symptomatology of PTSD was explored. To assess the role of VTA in PTSD, cells in this area were reversibly inactivated during a single exposure to inescapable foot-shock in a rodent model. Animals that underwent inactivation of VTA neurons decreased avoidance and lowered long-term anxiety-like behaviors in comparison with control groups. To assess short- and long-term electrophysiological effects of trauma on VTA cells, in vivo extracellular recordings were conducted. Results showed that the firing frequency of VTA cells changed both in the short- and long-term, following shock procedures. A human model of psychosical stress was used to test the hypothesis that the ability to respond appropriately to positive stimuli is important for the preservation of positive emotions following stressful events. The results show a positive correlation between trait resilience and trait reward sensitivity. To investigate the link between resilience and reward sensitivity further, the empirical portion of this study used a Monetary Incentive Delay Task (MID) to measure reward sensitivity before and after exposure to a psychosocial stressor. Moreover, behavioral reward sensitivity (as measured by MID and self-report satisfaction after the reward task) also correlated positively with trait and behaviorally measured resilience. The results shown in this dissertation suggest that the neural circuits involved in reward processing and reward function may be involved in resilient responses to stress.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Neuroscience
    Degree Grantor
    University of Arizona
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