PublisherThe University of Arizona.
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AbstractNitric oxide (NO) is a critical compound for many physiological processes and is closely connected to diseases such as cancer and pathophysiological conditions such as stroke and heart failure. NO synthesis is crucial for vasodilation and reduces blood clot formation. It is known to reduce glutathione (GSH), an inhibitor of cancer-therapy drugs, through oxidation of its thiol group. Combining chlorambucil, a chemotherapy drug that is used to treat chronic lymphocytic leukemia, and an NO releasing compound is projected to increase drug-therapy effectiveness on resistant cell line. Non-steroidal antiinflammatory drugs (NSAIDS) can also be combined with NO donors to create a drug that is both anti-inflammatory and anti-cancer.
Degree ProgramHonors College
Biochemistry and Molecular Biophysics