NO/HNO Releasing Derivatives of Chlorambucil and Aspirin
| dc.contributor.author | Giridharan, Kavya Sindhu | |
| dc.creator | Giridharan, Kavya Sindhu | en_US |
| dc.date.accessioned | 2012-09-13T22:25:03Z | |
| dc.date.available | 2012-09-13T22:25:03Z | |
| dc.date.issued | 2012-05 | |
| dc.identifier.citation | Giridharan, Kavya Sindhu. (2012). NO/HNO Releasing Derivatives of Chlorambucil and Aspirin (Bachelor's thesis, University of Arizona, Tucson, USA). | |
| dc.identifier.uri | http://hdl.handle.net/10150/243955 | |
| dc.description.abstract | Nitric oxide (NO) is a critical compound for many physiological processes and is closely connected to diseases such as cancer and pathophysiological conditions such as stroke and heart failure. NO synthesis is crucial for vasodilation and reduces blood clot formation. It is known to reduce glutathione (GSH), an inhibitor of cancer-therapy drugs, through oxidation of its thiol group. Combining chlorambucil, a chemotherapy drug that is used to treat chronic lymphocytic leukemia, and an NO releasing compound is projected to increase drug-therapy effectiveness on resistant cell line. Non-steroidal antiinflammatory drugs (NSAIDS) can also be combined with NO donors to create a drug that is both anti-inflammatory and anti-cancer. | |
| dc.language.iso | en | en_US |
| dc.publisher | The University of Arizona. | en_US |
| dc.rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. | en_US |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.title | NO/HNO Releasing Derivatives of Chlorambucil and Aspirin | en_US |
| dc.type | text | en_US |
| dc.type | Electronic Thesis | en_US |
| thesis.degree.grantor | University of Arizona | en_US |
| thesis.degree.level | bachelors | en_US |
| thesis.degree.discipline | Honors College | en_US |
| thesis.degree.discipline | Biochemistry and Molecular Biophysics | en_US |
| thesis.degree.name | B.S. | en_US |
| dc.description.admin-note | Removed permission form from PDF and replaced file June 2023 | |
| refterms.dateFOA | 2018-08-19T22:49:27Z | |
| html.description.abstract | Nitric oxide (NO) is a critical compound for many physiological processes and is closely connected to diseases such as cancer and pathophysiological conditions such as stroke and heart failure. NO synthesis is crucial for vasodilation and reduces blood clot formation. It is known to reduce glutathione (GSH), an inhibitor of cancer-therapy drugs, through oxidation of its thiol group. Combining chlorambucil, a chemotherapy drug that is used to treat chronic lymphocytic leukemia, and an NO releasing compound is projected to increase drug-therapy effectiveness on resistant cell line. Non-steroidal antiinflammatory drugs (NSAIDS) can also be combined with NO donors to create a drug that is both anti-inflammatory and anti-cancer. |
