PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractIn recent years scientists have been attempting to develop synthetic blood substitutes in order to counter both the shortage in donor blood and the problems associated with infection and disease during allogeneic transfusion. Most attempts have been made at mimicking the oxygen carrying capabilities of red blood cells yet there is still a broad array of substances in use today that try to simulate the effects of whole blood, not just the red blood cell itself. This literature based thesis extensively discuses the importance of all blood components and reviews the recent developments and problems associated with volume expanders, oxygen carriers which are further subcategorized into hemoglobin-based substitutes and perfluorocarbons, erythropoietin use, and autologous blood transfusions. Their short term use has potential benefits but in the long term some of their shortcomings include hypertension, hypoproteinemia, thrombus formation, abnormal vasoactivity, anaphylaxis, and ischemic reperfusion injury, all of which tend to overshadow their benefits.
Degree ProgramHonors College