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    The Role of Drosophila Neurexin-1 in Mushroom Body Development

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    azu_etd_mr_2012_0169_sip1_m.pdf
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    Author
    Shim, Kevin Guanwen
    Issue Date
    2012-05
    
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
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    Thesis Not Available (per Author's Request)
    Abstract
    Neurexins are transmembrane adhesion proteins that have a demonstrated role in proper synaptic function and protein organization. Neurexin-deficient laboratory animals have behavioral and learning deficits. In humans, NRXN mutations cause, and increase the risk of, a wide range of neurocognitive disorders including autism, intellectual disability, and schizophrenia. Here I report on the effect of loss-of-function mutations in the single NRXN ortholog found in fruit flies, Drosophila neurexin-1 (dnrx), on neuronal morphology. Limited evidence has suggested that neurexins play a role in cytoskeletal organization and in regulating dendritogenesis. This study aimed to answer the question of whether or not neurexin proteins are necessary for the inherent morphological organization of the neuron. My results indicate that dnrx mutants display no overall structural defects in mushroom body (MB) morphology in vivo, but their MB neurons have distinct morphological features when cultured and analyzed in vitro. Quantitative analysis of cultured mutant pupal brain neurons revealed distinct alteration in morphology that was selective to MB γ-neurons. This change manifests itself in a significant increase in higher-order branching and branchpoint density. I also report here on a novel vacuole phenotype observed in the cell bodies of cultured neurons.
    Type
    text
    Electronic Thesis
    Degree Name
    B.S.
    Degree Level
    bachelors
    Degree Program
    Honors College
    Molecular and Cellular Biology
    Degree Grantor
    University of Arizona
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    Honors Theses

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