Identifying Potential Candidate SNP's and Genes Linked to Handedness for Future Study
Publisher
The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
The goal was to identify genes for future study that might be linked to handedness for potential candidate gene study. We were able to find 3 major genes through statistically analyzing SNP data within a Genome-wide association Statistical Analysis tool, PLINK. 27 SNPs were chosen based on P-values of below .001, further analysis was done to these 27 SNPs to figure out their gene locus. Using NCBI we found 21 SNPs were within a gene locus. A total of 16 genes were found from the 21 SNPs that were located within a gene locus. Three extra genes were examined since they were located in a gene of interest CTNNA2. The genes found were further screened for high expression in subcortical regions and that have been implicated in neural function or brain development. Out of the 17 genes determined, IRAK2, NRG1, and CTNNA2 adhered to the criteria for screening.Type
textElectronic Thesis
Degree Name
B.S.Degree Level
bachelorsDegree Program
Honors CollegeMolecular and Cellular Biology