THE EFFECT OF CIMETIDINE, RANITIDINE, AND HALOTHANE ON LIDOCAINE PHARMACOKINETICS IN MAN.
AuthorGlass, Steven James.
Drugs -- Side effects.
Cimetidine -- Side effects.
Lidocaine -- Side effects.
Halothane -- Side effects.
Cimetidine -- Metabolism.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Degree ProgramGraduate College
Degree GrantorUniversity of Arizona
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Determination of the cost-effectiveness of a tuberculosis prevention program along the United States/Mexico border using Markov process modeling within a prevention effectiveness frameworkDraugalis, JoLaine R.; Borrego, Matthew Elvin, 1966- (The University of Arizona., 1998)A prevention effectiveness analysis framework was used to estimate the cost-effectiveness of a county administered tuberculosis prevention program along the U.S./Mexico border. The tuberculosis prevention program under study used prophylactic isoniazid therapy in patients who have tested positive for tuberculosis infection. This analysis determined the cost-effectiveness of the current program versus no program from the perspective of the county government and was modeled for two time periods; five years and 15 years post preventive therapy initiation. Costs were calculated using actual data from tuberculosis prevention and active tuberculosis treatment programs as well as hospital discharge data. The outcome of interest, cases of active tuberculosis averted, was calculated through a Monte Carlo simulated Markov process model. Average and incremental cost-effectiveness ratios were then calculated for the tuberculosis prevention program scenario. The cost-effectiveness ratios were calculated separately with the inclusion or exclusion of the tuberculosis contagion costs. The results of the cost-effectiveness ratio calculations established that the prevention of active tuberculosis cases with the tuberculosis prevention program is considerably cost-effective. Every baseline incremental cost-effectiveness ratio, across the five and 15 year analysis periods (irrespective of contagion costs) determined in this prevention effectiveness study demonstrated cost savings. Additionally, the cost savings were substantial. The results indicate that rather than incurring costs to avert active tuberculosis cases, the tuberculosis prevention program actually saves money. One-way sensitivity analyses were performed for selected parameters used in the calculation of the cost-effectiveness ratios. The cost-effective results obtained in the baseline analysis became sensitive when the percentage of patients hospitalized for tuberculosis decreased and when the preventive therapy compliance rate decreased for the 5 years post preventive treatment scenario with tuberculosis contagion costs excluded. However, when the tuberculosis contagion consequences of not having the tuberculosis prevention program were considered; the cost effectiveness and cost savings were once again realized.
The Auditor's Loss Function and Investors' Perceptions of Audit Effectiveness: Effects of Regulatory ChangeFelix, William L.; Smith, Jason Lance; Felix, William L.; Schatzberg, Jeffrey W.; Waller, William S. (The University of Arizona., 2008)In this dissertation, I examine the effects of regulatory changes that affect the auditor's loss function on investors' perceptions of audit effectiveness. Specifically, I examine two changes intended (1) to improve audit efficiency and (2) to reduce auditor liability exposure. The first regulatory change, which was recently enacted, is the replacement of Auditing Standard 2 (AS2) with Auditing Standard 5 (AS5). The second regulatory change, which is currently a hypothetical change, is the passage of litigation reform aimed at limiting the auditor's liability exposure following an alleged audit failure. I examine perceived audit effectiveness rather than actual effectiveness because actual audit effectiveness is unobservable by investors. In an experiment using 101 MBA students as proxies for individual investors, I find that both changes are perceived by investors as reducing the amount of testing performed by the auditor when performing the internal control audit. I also find that both regulatory changes negatively affect investors' perceptions of audit effectiveness. Following the change in the auditing standard, experienced and inexperienced investors predict opposite stock price movement and, as a result, make different investment allocation decisions. In performing supplemental analyses, I find significant gender differences in predicted future stock prices, but not in perceptions of audit effectiveness or in perceptions of internal control quality.
Effect of Plant Nitrogen Status on Effectiveness of Defoliants for Short Season Cotton ProductionNelson, J. M.; Hart, G.; Silvertooth, Jeff; Bantlin, Marguerite (College of Agriculture, University of Arizona (Tucson, AZ), 1991)A field study was conducted at the Maricopa Agricultural Center to determine the influence of nitrogen fertility level on the effectiveness of defoliants for short-season cotton production. Increasing the nitrogen fertility level from 30 to 130 lbs N/A decreased lint yields from 3.2 to 26 bales /A. High residual soil N favored the use of a low N fertility rate. Defoliation treatments were most effective at the 30 lbs. N/A fertility level. Increasing the application rate of Dropp from 0.2 to 0.4 lbs. a.i./A increased the percent defoliation. There was a significant linear decrease in the effectiveness of defoliants as the petiole NO₃-N content increased from 300 to 7000 ppm.