THE EFFECT OF CIMETIDINE, RANITIDINE, AND HALOTHANE ON LIDOCAINE PHARMACOKINETICS IN MAN.
AuthorGlass, Steven James.
Drugs -- Side effects.
Cimetidine -- Side effects.
Lidocaine -- Side effects.
Halothane -- Side effects.
Cimetidine -- Metabolism.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Degree ProgramGraduate College
Degree GrantorUniversity of Arizona
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THE EFFECT OF COHERENT MAGNETIC BREAKDOWN ON THE DE HAAS - VAN ALPHEN EFFECT IN MAGNESIUMStark, Royal W.; Eddy, James Walter (The University of Arizona., 1980)We report here the results of a de Haas-van Alphen (dHvA) investigation of the coupled orbit system in magnesium. The data were taken for magnetic fields extending to 52 kG and temperatures down to 0.29° K. The experimental data are interpreted in the light of coupled orbit system theories of Pippard and of Falicov and Stachowiak; these are each reviewed in some detail. The data are found to disagree qualitatively with the predictions of Falicov and Stachowiak. Since this theory has been assumed, for more than a decade, to be equivalent to Pippard's theory, a detailed comparison of these was made. Full spectrum Fourier analysis of Pippard's band structure density of states shows that the two models disagree qualitatively and, therefore, that they are not equivalent. These experimental results, which do not appear to disagree with Pippard's theory, are interpreted to mean that it is fnally possible to obtain crystals of sufficient purity and perfection to make it necessary to use a band structure description of the delocalized electrons on the couple network. Evidence is presented for the existence of a new type of dHvA frequency corresponding to the ΓKM plane cross-section of the Brillouin zone. A proposed explanation for this dHvA frequency involves the field dependent modulation of the zero frequency component of the Fourier transform of the coupled orbit system density of states. Also included are discussions of crystal preparation and handling, cryogenic apparatus, analogue detection apparatus, digital data acquisition and processing hardware based on a microcomputer, and a new software system ideally suited to small computer research environments.
EFFECTS OF CONSULTATION AND SUPPLEMENTAL EDUCATION FOR THALASSEMIA PATIENTS ON EFFECTIVE TREATMENT AND CAREBhasin, Neha; TALWAR, SIDDHANT (The University of Arizona., 2016)Thalassemia is a genetic disorder that is characterized by abnormal hemoglobin within red blood cells of the body. If not diagnosed early and treated with proper care, this disorder is fatal. Once considered rare, this disorder’s rise in prevalence is now of concern to many health professionals because it does not receive the same level of attention as other, more common blood disorders. Due to its chronic treatment course and recent advancements in treatment, thalassemia still remains primarily a pediatric disorder not having many cases of patients living into adulthood at this point in time . Seeing this shortcoming in thalassemia advocacy we find it useful to take certain steps to bring more public awareness of it. We hope to share information about this debilitating disorder, its management/ treatment course and most importantly, its prevention through genetic testing. We conducted a patient quality improvement study at the Pediatric Hematology/Oncology/BMT clinic at Banner University Medical Center Tucson, AZ to assess the effectiveness of consultations and supplemental education on the treatment and care of thalassemia patients. The focus of the project revolved around patients with the most prominent thalassemias, beta and alpha.
Stream-Aquifer Interactions: Its Effects on Nutrient Variability, its Role on Streamflow Permanence and the Effects of Temperature Measurement Resolution on its QuantificationMeixner, Thomas; Soto, Carlos Daniel; Ferré, Ty P.A.; McIntosh, Jennifer; Pelletier, Jon (The University of Arizona., 2018)In semi-arid river systems, the connectivity and interaction between the stream and its aquifer is an important hydrologic linkage that affects the presence and quantity of streamflow, and the biogeochemical processes occurring in the stream, its streambed and aquifer. The work presented here builds upon and intends to expand on the knowledge base of stream-aquifer interaction by focusing on three main study areas. First, a descriptive and process based study evaluates how changes in basin groundwater (BGW) contribution to streamflow in the San Pedro River translate to changes in its chemical composition (nitrogen, metals and dissolved organic carbon) and proposes mechanisms that could explain the observed relationships. Second, an experimental and process based study evaluates how an empirically derived predictive model can use and predict streamflow permanence (wet/dry areas) on the San Pedro River from a set of geomorphic and hydrologic variables. Third, a methodological investigation of an idealized system that evaluates the effect of temperature measurement resolution on the estimations of stream-aquifer flux using temperature as a tracer. Major findings of this work show that in the San Pedro River: 1) BGW contribution and its variability increases with downstream distance and time since last flooding; 2) the concentrations, variability and spatial dependence of several chemical species are associated and follow similar patterns with BGW contribution; and 3) an empirical model using variables that describe bedrock elevation, the shape and width of the floodplain, the land surface elevation, and late spring streamflow can be used to correctly predict 80-87% of the wet/dry location in the river. In addition, this study found that temperature measurement resolution introduces large estimation errors when temperature amplitude is used as a predictor of stream-aquifer flux, and that it limits the range over which vertical stream-aquifer fluxes can be accurately estimated more than temperature measurement, placement and thermal parameter uncertainty.