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    The effects of retinoids and carotenoids on the in vitro function of human monocytes treated with ultraviolet light

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    Author
    Schoen, David Jay, 1962-
    Issue Date
    1987
    Keywords
    Ultraviolet radiation -- Physiological effect.
    Retinoids.
    Carotenoids.
    Monocytes.
    Immunity -- Nutritional aspects.
    Advisor
    Watson, Ronald R.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Human peripheral blood monocytes provide a model for the in vivo exposure to, and immune functional damage caused by chronic UVB exposure at the skin surface. Retinoids and carotenoids are known immune function enhancers; they can also prevent cellular toxic product formation caused by UVB exposure. Application of these compounds in vitro may prevent functional damage to monocytes. Monocytes were exposed in vitro to UVB, then assayed for cytotoxic, phagocytic, and antigen presenting abilities. Phagocytic activity was protected from UVB damage by exposure to these compounds; cytotoxic activity was not altered by UVB exposure, but increased by retinoid or carotenoid exposure. Antigen presentation was not affected by either the UVB or these compounds. Protection of phagocytic function was not due to release of activating monokines or prostaglandins. Instead, the cell membrane antioxidant properties of these retinoids or carotenoids were the factors that protected the monocyte from phagocytic damage caused by UVB exposure.
    Type
    text
    Thesis-Reproduction (electronic)
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Microbiology and Immunology
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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