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    A theoretical and experimental study of the feasibility of high temperature ultrasound hyperthermia

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    Author
    Billard, Bonnie Elizabeth, 1964-
    Issue Date
    1989
    Keywords
    Thermotherapy.
    Cancer -- Thermotherapy.
    Ultrasonic waves -- Therapeutic use.
    Advisor
    Roemer, Robert B.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The purpose of this research was to investigate the feasibility of using high temperature ultrasonic pulses to administer therapeutic hyperthermia treatments independent of changes in blood perfusion and tissue properties. The use of a computer simulation program was used to study the effects of blood perfusion, tissue properties, transducer characteristics, and treatment geometry on the temperature elevation and thermal dose delivered by short high temperature ultrasonic pulses. Experiments were conducted in vitro and in vivo to investigate the effects of blood perfusion changes. Other experiments were carried out in dog thigh muscle to determine the effects of changes in tissue properties. A final study was done where murine melanoma in mice were treated with high temperature ultrasound. Results show that shorter pulse lengths (≤ 2 s) and smaller focal diameters (≤ 3 mm) give practically perfusion independent temperature elevation and thermal dose. Normal fluctuations in tissue properties should not have a significant effect on the treatment provided that proper choice of transducer is made for each individual application. High temperature ultrasonic pulses have also been shown to induce tumor responses. Based on this research, this technique is a feasible means of administering hyperthermia for cancer therapy.
    Type
    text
    Thesis-Reproduction (electronic)
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Aerospace and Mechanical Engineering
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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