Longitudinal changes in cellular immunity in the first year of life and lack of relationship to serum immunoglobulin-E
AuthorStern, Debra Ann, 1958-
KeywordsCellular immunity -- Longitudinal studies.
Infants -- Nutrition -- Immunological aspects.
Newborn infants -- Immunology.
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PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractThe present study was undertaken to explore the relationship of cellular immunity to total serum ICE in an unselected sample of 278 healthy infants. Statistical analyses of infant history profiles and cellular immune and serum IgE determinations from cord blood and 10 month samples were performed using SPSSx. During the first year of life, the percent CD3, CD4, CD8, ERFC, and B-cell counts significantly increased and the CD4/CD8 ratio and responses to ConA and PW mitogens significantly decreased. Boys had lower percent CD8 cell counts and decreased responses to ConA and PW mitogens in cord blood. Cellular immune variable values were not associated with total serum ICE in any analysis. Early feeding method had no effect on 10 month serum IgE levels or cellular immune variables. Cord blood percent CD3 and CD4 cell counts were significantly decreased in infants with parental histories of asthma. In summary, (1) boys had a lower percent of suppressor T-cells and lower mitogen responses in cord blood (2) boys and girls reached similar levels for all variables by 10 months of age (3) infants with familial histories of asthma had fewer total and helper T-cells in cord blood.
Degree ProgramGraduate College
Microbiology and Immunology