Influence of copper deficiency on plasma lipoproteins and the development of enlarged plasma volume and cholesterol pool size
| dc.contributor.advisor | Lei, K. Y. | en_US |
| dc.contributor.author | Al-Othman, Abdullah Abdulrahman, 1961- | |
| dc.creator | Al-Othman, Abdullah Abdulrahman, 1961- | en_US |
| dc.date.accessioned | 2013-03-28T10:29:24Z | |
| dc.date.available | 2013-03-28T10:29:24Z | |
| dc.date.issued | 1989 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10150/277117 | |
| dc.description.abstract | Two studies were designed to investigate the time course development of enlarged plasma volume and cholesterol pool size in copper (Cu)-deficient rats as well as influence of Cu deficiency on the lipid composition of lipoproteins. Rats were randomly assigned to three dietary Cu treatments (deficient, marginal, and adequate) in the Study I and two dietary Cu treatments (deficient and adequate) in Study II. Enlargement of plasma volume and cholesterol pool size were established prior to the increase in plasma cholesterol concentration. Cu concentration was decreased, whereas iron and zinc concentrations were increased in the organs of Cu-deficient and Cu-marginal rats. The plasma pool size of VLDL triglyceride was elevated 6-fold, protein and phospholipid were unaltered, and cholesterol was reduced 36%. The plasma pool size of lipid and protein components of HDL and LDL fractions were markedly elevated in Cu-deficient rats. | |
| dc.language.iso | en_US | en_US |
| dc.publisher | The University of Arizona. | en_US |
| dc.rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. | en_US |
| dc.subject | Copper in animal nutrition. | en_US |
| dc.subject | Blood lipoproteins. | en_US |
| dc.subject | Cholesterol -- Bioaccumulation. | en_US |
| dc.subject | Blood plasma. | en_US |
| dc.subject | Hypocupremia -- Complications. | en_US |
| dc.title | Influence of copper deficiency on plasma lipoproteins and the development of enlarged plasma volume and cholesterol pool size | en_US |
| dc.type | text | en_US |
| dc.type | Thesis-Reproduction (electronic) | en_US |
| dc.identifier.oclc | 23156843 | en_US |
| thesis.degree.grantor | University of Arizona | en_US |
| thesis.degree.level | masters | en_US |
| dc.identifier.proquest | 1338080 | en_US |
| thesis.degree.discipline | Graduate College | en_US |
| thesis.degree.discipline | Nutritional Sciences | en_US |
| thesis.degree.name | M.S. | en_US |
| dc.identifier.bibrecord | .b17583317 | en_US |
| refterms.dateFOA | 2018-09-04T04:13:02Z | |
| html.description.abstract | Two studies were designed to investigate the time course development of enlarged plasma volume and cholesterol pool size in copper (Cu)-deficient rats as well as influence of Cu deficiency on the lipid composition of lipoproteins. Rats were randomly assigned to three dietary Cu treatments (deficient, marginal, and adequate) in the Study I and two dietary Cu treatments (deficient and adequate) in Study II. Enlargement of plasma volume and cholesterol pool size were established prior to the increase in plasma cholesterol concentration. Cu concentration was decreased, whereas iron and zinc concentrations were increased in the organs of Cu-deficient and Cu-marginal rats. The plasma pool size of VLDL triglyceride was elevated 6-fold, protein and phospholipid were unaltered, and cholesterol was reduced 36%. The plasma pool size of lipid and protein components of HDL and LDL fractions were markedly elevated in Cu-deficient rats. |
