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    The scientific validity of the standards for 1,2-dibromoethane

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    Author
    Pike, Steven, 1951-
    Issue Date
    1990
    Keywords
    Ethylene dibromide -- Toxicology.
    Advisor
    Sipes, I. Glenn
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    1,2-Dibromoethane (DBE) is a nematocide used extensively to control fruitfly and other larvae that feed on fruit and grain and as a lead scavenger in gasoline additives. DBE is extremely toxic to animals at relatively low doses and is carcinogenic in chronic animal studies on mice and rats. The lack of good human epidermiologic data resulted in the reliance of quantitative risk assessment techniques by the Environmental Protection Agency (EPA) for severely limiting its use as a fumigant for grain in 1984, and the Occupational Safety and Health Administration (OSHA) for lowering workplace standards from 20 parts per million (ppm) to 0.1 ppm. This thesis reviews the metabolic, animal, and human studies used for the extrapolation, the mathematical models available, the assumptions made for the data and model chosen, and discusses the validity of the resultant process for setting standards for DBE exposure.
    Type
    text
    Thesis-Reproduction (electronic)
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Toxicology
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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