Evaluation of diagnostic clues in histopathology through image processing techniques
AuthorHaddad, Jane Wurster, 1965-
Engineering, Electronics and Electrical.
Health Sciences, Pathology.
AdvisorSchowengerdt, R. A.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractThe primary method for the diagnostic interpretation of histopathologic sections is visual analysis. However, in a small, but significant percentage of cases, histopathologists do not come to a consensus. Therefore, due to the importance of early and accurate detection of tissue changes indicative of pathology, quantitative image analysis techniques have been applied to this problem. The accurate segmentation of image structures such as cells and glands in histopathological sections, as with all "natural scenes", proves challenging. This has led to the development of an additional segmentation technique, the heuristic gradient search. Following the successful segmentation and labeling of scene objects, algorithms evaluating diagnostic clues as to the shape, size and distribution of image components were developed in order to form an overall diagnosis. A description of these diagnostic clues and the image processing techniques residing in the computer vision system used to evaluate them are presented.