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dc.contributor.advisorMcNamara, Donald J.en_US
dc.contributor.authorIbrahim, Jamal Bachir Taher, 1961-
dc.creatorIbrahim, Jamal Bachir Taher, 1961-en_US
dc.date.accessioned2013-03-28T10:36:44Z
dc.date.available2013-03-28T10:36:44Z
dc.date.issued1990en_US
dc.identifier.urihttp://hdl.handle.net/10150/277312
dc.description.abstractThe effects of dietary saturated versus polyunsaturated fat (7.5%; w/w) on sterol balance and lipoprotein metabolism were studied in guinea pigs. The polyunsaturated diet significantly reduced plasma cholesterol and triglyceride levels by 34% and 40%, respectively. Polyunsaturated dietary fat significantly reduced the percentage of cholesteryl ester in low density lipoprotein (LDL) while the relative proportion of LDL-phospholipids was increased. The ratio of LDL surface to core components in the polyunsaturated fed animals was significantly higher (P .02). Dietary fat quality had no effect on either sterol balance or hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Hepatic free and esterfield cholesterol levels were significantly higher in the polyunsaturated fat fed group (P .01). Feeding polyunsaturated fat caused a significant (1.9-fold) increase in hepatic membrane LDL (apo B/E) receptor binding. The data indicate that the hypocholesterolemic effect of polyunsaturated fat is not attributable to changes in cholesterol metabolism but rather to a redistribution of plasma cholesterol to tissues due to increased tissue LDL receptor binding.
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectAgriculture, Food Science and Technology.en_US
dc.subjectHealth Sciences, Nutrition.en_US
dc.titleThe effects of dietary fat quality on cholesterol and lipoprotein metabolism in the guinea pigen_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.levelmastersen_US
dc.identifier.proquest1340708en_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineNutrition and Food Sciencesen_US
thesis.degree.nameM.S.en_US
dc.identifier.bibrecord.b26281612en_US
refterms.dateFOA2018-07-13T02:35:41Z
html.description.abstractThe effects of dietary saturated versus polyunsaturated fat (7.5%; w/w) on sterol balance and lipoprotein metabolism were studied in guinea pigs. The polyunsaturated diet significantly reduced plasma cholesterol and triglyceride levels by 34% and 40%, respectively. Polyunsaturated dietary fat significantly reduced the percentage of cholesteryl ester in low density lipoprotein (LDL) while the relative proportion of LDL-phospholipids was increased. The ratio of LDL surface to core components in the polyunsaturated fed animals was significantly higher (P .02). Dietary fat quality had no effect on either sterol balance or hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Hepatic free and esterfield cholesterol levels were significantly higher in the polyunsaturated fat fed group (P .01). Feeding polyunsaturated fat caused a significant (1.9-fold) increase in hepatic membrane LDL (apo B/E) receptor binding. The data indicate that the hypocholesterolemic effect of polyunsaturated fat is not attributable to changes in cholesterol metabolism but rather to a redistribution of plasma cholesterol to tissues due to increased tissue LDL receptor binding.


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