Reticuloendothelial clearance and gastrointestinal absorption of polystyrene latex particles: Possible applications to the external scanning of tumors
AdvisorOlson, George B.
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PublisherThe University of Arizona.
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AbstractThe use of 153Sm-incorporated polystyrene latex particles for the external image scanning of tumors was simulated in four murine strains. Reticuloendothelial blood clearance and tissue localization of 0.5 mum and 1.0 mum fluorescent PSL was evaluated in RE-competent and RE-depressed mice following IV injection and oral particle administration. Intravenous injection of PSL revealed differences in blood clearance rates and tissue distribution patterns with respect to strain and particle size; an explanation based on genetic strain derivation is offered. RE depression in the Balb/c resulted in higher circulating blood levels of both particle sizes without affecting tissue distribution patterns; the use of dissimilarly sized particles for blocking and testing resulted in dramatic decreases in organ PSL concentrations and alterations in apparent kinetic rate constants. Balb/c blood levels of orally administered particles were increased and remained temporally constant while tissue concentrations were generally lower than IV-injected levels.
Degree ProgramGraduate College
Microbiology and Immunology