Hepatic drug clearance of three model compounds in normal subjects and cancer patients
KeywordsHealth Sciences, Pharmacology.
AdvisorAlberts, David S.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractHepatic drug clearance (HDC) plays a fundamental role in the metabolism and disposition of xenobiotics. Numerous methods of assessing HDC have been proposed in an effort to elucidate the genetic and extra-genetic effects upon xenobiotic biotransformation. One such method incorporates the co-administration of three model compounds to assess three unique parameters of HDC; namely, hepatic blood flow, Phase I (microsomal-mediated oxidative) metabolism, and Phase II (synthesis/conjugation) reactions. Pharmacokinetic studies of indocyanine green, antipyrine, and lorazepam were undertaken to assess each HDC parameter, respectively. This method was utilized to define differences in HDC between normal, healthy, young males and an older group with cancer.
Degree ProgramGraduate College
Pharmacology & Toxicology