Spontaneous congenital heart malformations in the Sprague-Dawley rat
AuthorJohnson, Paula Denise, 1959-
AdvisorDawson, Brenda V.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractThe spontaneous rate of congenital cardiac defects in the commonly used Sprague-Dawley rat has not been extensively researched. The incidence of general congenital defects has been studied thoroughly and reported as very low incidence in this rat. Teratology studies using mammalian models are of increasing importance as the number of environmental contaminants increases. It is essential to know if the spontaneous congenital cardiac defect rate of this most common mammalian model in order to plan statistically appropriate research protocols. Using a thorough and detailed method of evaluating the structure of the Sprague-Dawley fetal rat heart, 624 fetal rat hearts were examined at term, just prior of delivery. The overall incidence of spontaneous congenital cardiac defects is 2.3%. This is similar to the incidence in man and thus enhances the suitability of the Sprague-Dawley rat as a small mammalian model for research into cardiac teratogenesis.