Cardiac arrhythmias and acute rejection in human to human cardiac transplantation; an exploratory study
AdvisorGerber, Rose M.
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PublisherThe University of Arizona.
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AbstractAn exploratory study design was used to describe the relationship between the degree of acute rejection and the presence of cardiac arrhythmias in cardiac transplant patients. The frequencies and types of cardiac arrhythmias were observed in relationship to the results of endomyocardial biopsy and the serum T cell levels. A retrospective primary review of records was conducted utilizing 42 cardiac transplant recipients with a total of 128 endomyocardial biopsy procedures, the unit of analysis. In general, more cardiac arrhythmias were recorded after endomyocarial biopsy than before and the majority were atrial type arrhythmias, followed by ventricular and junctional arrhythmias. The significant relationships occurred between conduction arrhythmias, both frequency and type, and acute rejection. However, very small numbers of conduction arrhythmias were reported. Previous relationships between cardiac arrhythmias in general and acute rejection were not supported, possibly due to the effects of cyclosporine (Sandimmune).
Degree ProgramGraduate College