• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    The immunomodulatory effect of antioxidants in murine retrovirus-infected mice: Treatment opportunity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_td_9960293_sip1_w.pdf
    Size:
    9.413Mb
    Format:
    PDF
    Download
    Author
    Lee, Jeongmin
    Issue Date
    1999
    Keywords
    Health Sciences, Nutrition.
    Health Sciences, Immunology.
    Advisor
    Watson, Ronald R.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The acquired immune deficiency syndrome (AIDS) is a clinical disorder caused by the human immunodeficiency virus (HIV) that induced severe immunosuppression, rendering the body highly susceptible to opportunistic infection. As HIV-infected persons survive previously life-threatening infection through the use of effective medical therapies, malnutrition has become central issues in the health care plan of long-term survivors. Nutrition is a fundamental intervention in the early and ongoing treatment of HIV disease. Nutrition therapy, in coordination with other medical interventions, can extend and improve the quality and quantity of life in individuals infected with HIV and living with AIDS. A murine AIDS (MAIDS) model, induced by LP-BM5 murine leukemia virus, has been an effective tool to investigate mechanisms of retrovirus-induced immunodeficiency. The MAIDS animal model displays a number of the features of human AIDS, including progressive lymphoproliferation and increasing severe immunodeficiency. The present studies suggested that micronutrient deficiency resulted in premature death and immune dysfunction beyond immune suppression induced by LP-BM5. Chronic EtOH consumption in murine retrovirus-infected mice caused deleterious effects on host defense, immune response, cytokine release, oxidative stress, and nutritional status. This immune dysfuction happened more severely with aging. Supplementation with antioxidants prevented retrovirus-induced suppression of immune response and prolonged the survival of retrovirus-infected mice. It maintained nearly normal cytokine production. This occurred simultaneously with restoration of tissue vitamin E and T- and B-cell proliferation. DHEAS accentuated the effects of antioxidants and maintained cytokine production, T- and B-cell proliferation, and hepatic vitamin E close to the activity level of the uninfected mice.
    Type
    text
    Dissertation-Reproduction (electronic)
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Nutritional Sciences
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.