• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Dietary fat association with nonmelanoma skin cancer among predisposed individuals

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_td_9983864_sip1_m.pdf
    Size:
    3.953Mb
    Format:
    PDF
    Download
    Author
    Foote, Janet Anne
    Issue Date
    2000
    Keywords
    Health Sciences, Nutrition.
    Health Sciences, Public Health.
    Advisor
    Giuliano, Anna R.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Although cell and animal studies support an association between nonmelanoma skin cancer and dietary fat, few studies have assessed this relationship among humans. This study assessed the relationship among participants in a five-year chemoprevention trial completed at the Arizona Cancer Center. This design allowed efficient investigation into the association of dietary fat with development of skin basal (BCC) and squamous cell carcinoma (SCC) among high risk individuals. Three manuscripts were written to examine the dietary characteristics of the study population, factors associated with basal and squamous cell skin cancer occurrence, and the association of dietary fat and other dietary components with skin cancer incidence. The hypothesis was that dietary fat, and linoleic acid in particular, would increase the risk of SCC occurrence. Using a semi-quantitative food frequency questionnaire, usual dietary intake of the volunteers, aged 51 to 85 years, was generally consistent with intakes reported by other studies. However, more than half of the participants consumed less than the recommended levels of vitamin D, folate, calcium, and dairy and grain foods. Among participants randomly assigned to the control intervention with no prior history of skin cancer, the incidence of BCC and SCC was 3629 and 2671 per 100,000 person-years, respectively. Only age independently predicted BCC incidence, while male gender, naturally red hair color, years of residency in Arizona as an adult, and age predicted SCC incidence. Dietary fat was not associated with the development of BCC among these high risk individuals. Estimated daily intake of total fat and oleic acid were weakly associated with SCC occurrence (p = 0.09 and p = 0.06) and linoleic acid was not associated. Neither total dietary fat nor any specific fatty acid were associated with reduction in time to first occurrence or total number of skin cancers. Dietary vitamin C and vitamin E, antioxidants that could potentially reduce cellular protein damage from the oxidative compounds formed by ultraviolet penetration, were also not associated with BCC or SCC development.
    Type
    text
    Dissertation-Reproduction (electronic)
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Nutritional Sciences
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.