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dc.contributor.advisorYalkowsky, Samuel H.en_US
dc.contributor.authorKrzyzaniak, Joseph Frances, 1968-*
dc.creatorKrzyzaniak, Joseph Frances, 1968-en_US
dc.date.accessioned2013-05-09T09:01:32Z
dc.date.available2013-05-09T09:01:32Z
dc.date.issued1997en_US
dc.identifier.urihttp://hdl.handle.net/10150/288713
dc.description.abstractThe primary focus of this research is to develop an in vitro method that uses an appropriate formulation:blood ratio and contact time to evaluate the degree of hemolysis occurring after an intravenous injection. The effects of both the formulation composition and the formulation:blood contact time on hemolysis are given in Chapters I-IV. Since hemolysis is shown to increase as either the formulation:blood ratio and/or the contact time increases for various pharmaceutical vehicles, a small formulation:blood ratio and short contact time must be selected to determine the degree of hemolysis occurring as the formulation is rapidly diluted by the blood after an intravenous injection. Using a formulation:blood ratio of 0.1 and a contact time of 1 second, a dynamic method has been developed to evaluate intravascular hemolysis. The ability of this method to accurately evaluate hemolysis occurring after an injection is determined by comparing hemolysis data generated with this dynamic method to in vivo hemolysis data obtained from the literature. The results of this comparison are given in chapter V. The in vitro hemolysis data are shown to be in agreement with in vivo hemolysis data.
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectHealth Sciences, Toxicology.en_US
dc.subjectChemistry, Pharmaceutical.en_US
dc.subjectHealth Sciences, Pharmacy.en_US
dc.titleA new in vitro method for evaluating intravascular hemolysisen_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.leveldoctoralen_US
dc.identifier.proquest9806780en_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmaceutical Sciencesen_US
thesis.degree.namePh.D.en_US
dc.identifier.bibrecord.b37529626en_US
refterms.dateFOA2018-06-12T08:49:36Z
html.description.abstractThe primary focus of this research is to develop an in vitro method that uses an appropriate formulation:blood ratio and contact time to evaluate the degree of hemolysis occurring after an intravenous injection. The effects of both the formulation composition and the formulation:blood contact time on hemolysis are given in Chapters I-IV. Since hemolysis is shown to increase as either the formulation:blood ratio and/or the contact time increases for various pharmaceutical vehicles, a small formulation:blood ratio and short contact time must be selected to determine the degree of hemolysis occurring as the formulation is rapidly diluted by the blood after an intravenous injection. Using a formulation:blood ratio of 0.1 and a contact time of 1 second, a dynamic method has been developed to evaluate intravascular hemolysis. The ability of this method to accurately evaluate hemolysis occurring after an injection is determined by comparing hemolysis data generated with this dynamic method to in vivo hemolysis data obtained from the literature. The results of this comparison are given in chapter V. The in vitro hemolysis data are shown to be in agreement with in vivo hemolysis data.


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