Solubilization of drugs. Formulation development perspective

Abstract

This dissertation discusses some aspects of the solubilization of drugs from the perspective of the formulator. Chapter I emphasizes the importance of this research as well as the study of the practical aspects of aqueous solubilization of drugs. The most important solubilization techniques such as pH control, cosolvency, micellization, and complexation are introduced in Chapter II. Chapter III evaluates specifically the cosolvency technique by means of a discussion of the effect of pharmaceutically acceptable cosolvents upon the solubilization of several drugs. Chapter IV discusses the micellization technique in detail. In this chapter, the effect of Tween 80 on the solubilization of several drugs is evaluated. Finally, in Chapter V, the consequences of the dilution of a pH solubilized formulation are evaluated by means of two in vitro formulation dilution methods.