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dc.contributor.advisorYalkowsky, Samuel H.en_US
dc.contributor.authorAlvarez-Nunez, Fernando Antonio
dc.creatorAlvarez-Nunez, Fernando Antonioen_US
dc.date.accessioned2013-05-09T09:25:04Zen
dc.date.available2013-05-09T09:25:04Zen
dc.date.issued1999en_US
dc.identifier.urihttp://hdl.handle.net/10150/289009en
dc.description.abstractThis dissertation discusses some aspects of the solubilization of drugs from the perspective of the formulator. Chapter I emphasizes the importance of this research as well as the study of the practical aspects of aqueous solubilization of drugs. The most important solubilization techniques such as pH control, cosolvency, micellization, and complexation are introduced in Chapter II. Chapter III evaluates specifically the cosolvency technique by means of a discussion of the effect of pharmaceutically acceptable cosolvents upon the solubilization of several drugs. Chapter IV discusses the micellization technique in detail. In this chapter, the effect of Tween 80 on the solubilization of several drugs is evaluated. Finally, in Chapter V, the consequences of the dilution of a pH solubilized formulation are evaluated by means of two in vitro formulation dilution methods.
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectChemistry, Pharmaceutical.en_US
dc.subjectHealth Sciences, Pharmacy.en_US
dc.titleSolubilization of drugs. Formulation development perspectiveen_US
dc.typetexten_US
dc.typeDissertation-Reproduction (electronic)en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.leveldoctoralen_US
dc.identifier.proquest9946790en_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplinePharmacy Practice and Scienceen_US
thesis.degree.namePh.D.en_US
dc.identifier.bibrecord.b39904714en_US
refterms.dateFOA2018-08-20T05:15:03Z
html.description.abstractThis dissertation discusses some aspects of the solubilization of drugs from the perspective of the formulator. Chapter I emphasizes the importance of this research as well as the study of the practical aspects of aqueous solubilization of drugs. The most important solubilization techniques such as pH control, cosolvency, micellization, and complexation are introduced in Chapter II. Chapter III evaluates specifically the cosolvency technique by means of a discussion of the effect of pharmaceutically acceptable cosolvents upon the solubilization of several drugs. Chapter IV discusses the micellization technique in detail. In this chapter, the effect of Tween 80 on the solubilization of several drugs is evaluated. Finally, in Chapter V, the consequences of the dilution of a pH solubilized formulation are evaluated by means of two in vitro formulation dilution methods.


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