Synergistic solubilization

Abstract

This Dissertation presents a number of projects and novel ideas related to pharmaceutical solution chemistry, including: combination solubilization and formulation techniques, predictive modeling methods, and experimentally demonstrated complexation theory. Chapter 1 presents both the underlying theory and experimental results of a formulation project for a novel anticancer drug which resulted in an 8,000-fold increase in solubility. Chapter 2 presents an extensive computer and literature-based predictive model for the estimation of cosolvent solubilization. Finally, Chapter 3 presents an exhaustive theoretical derivation with experimental validation of a novel method to determine complexation stability constants in mixed stoichiometric systems of cyclodextrin complexes.