• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Studies on tumor promotion and progression: The importance of signaling by activator protein-1 and prostaglandin E₂

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_td_3073265_sip1_m.pdf
    Size:
    2.571Mb
    Format:
    PDF
    Download
    Author
    Thompson, Eric J.
    Issue Date
    2002
    Keywords
    Biology, Molecular.
    Health Sciences, Toxicology.
    Health Sciences, Oncology.
    Advisor
    Bowden, G. Tim
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    It is clear that non-melanoma skin cancers have a significant impact on the health of the general population. With over one million new cases expected this year the extent of the problem is increasing. Extensive research on the molecular mechanisms of tumor promoting agents has yielded a large body of evidence suggesting that activity of the transcription factor activator protein-1 is central to development of benign lesions. Recently, a dominant negative c jun, TAM-67, has been shown to block tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. In order to determine if this is a more general phenomenon, we examined the effects of TAM-67 on okadaic acid induced tumor promotion. We found that TAM-67 could effectively inhibit tumorigenesis induced by okadaic acid. In order to further characterize the activity of TAM-67, we identified its molecular mechanism of action in suppressing okadaic acid induced activator protein-1 activity. These studies led to identification of squelching as the mechanism of action. This work also revealed that TAM-67 could interact with all the proteins of the Jun and Fos families as well as non-activator protein-1 proteins. Thus, TAM-67 may be able to affect multiple pathways including activator protein-1. Other work has identified prostaglandin signaling as a major factor in the development of non-melanoma skin cancer. We identified production of prostaglandin E2 as one of the abnormalities in a model of skin tumor progression. The cell lines examined were able to make prostaglandin E2, and also expressed receptors for it. We therefore examined the importance of this apparent autocrine loop and found that the cells that produce prostaglandin E2 depend on signaling from the prostaglandin E2 receptor EP1 for a normal in vitro growth rate. Both transactivation by activator protein-1 and signaling by prostaglandins are involved in chemically induced skin carcinogenesis. The magnitude of the problem ensures that demand for new treatments will only increase. Obtaining a clear understanding of the molecular events associated with the growth and transformation of cells from normal to benign to malignant is crucial to identifying novel treatment and prevention strategies.
    Type
    text
    Dissertation-Reproduction (electronic)
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Pharmacology & Toxicology
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.